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时间:2018-12-03
《2011~2015年合肥市手足口病流行病学及病原学特征分析》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、2011〜2015年合肥市手足口病流行病学及病原学特征分析吴金菊尤恩情张文艳金晶赵科伕朱义彬张磊汤仁树安徽省合肥市疾病预防控制中心摘要:目的分析20112015年合肥市手足口病的流行病学和病原学特征,为手足口病的防控工作提供参考。方法手足口病发病资料来自201P015年传染病监测报告信息管理系统,病原学检测数据来自监测点和现场调查采样,统计方法运用描述性分析和x2检验,对粪便标本采用RT-PCR扩增基因序列测定,并利用生物学软件分析。结果手足口病年平均发病率196.11/10万,发病高峰在46月,发病年龄以5岁以下儿童为主,占总发病人数的94.45%;肠道病
2、毒71型(EV71)为优势株,感染机体引起重症手足口病风险较大。进化树分析表明合肥市EV71属于C4a亚型。幼儿园健康儿童病毒携带率6.80%,均为其它肠道病毒。结论合肥市手足门病发病率较高,EV71是优势株,为C4a亚型,与屮国大陆优势毒株流行趋势一致。在做好全面防控的同时,应重点做好5岁以下儿童的防控工作。关键词:手足LI病;流行特征;肠道病毒71型;收稿日期:2017-04-17基金:合肥市科技局自筹资金项目(项目编号:合科[2012]121号)Epidemiologicalandetiologicalcharacteristicsofhand,foo
3、tandmouthdiseaseinHefeifrom2011to2015WUJiniuYOUEnqingZHANGWenyanHefeiCenterForDiseaseControlAndPrevention;Abstract:ObjectiveToanalyzetheepidemiologyandetiologyofhand,footandmouthdisease(IIFMD)inHefeicityfrom2011to2015soastoprovidescientificevidenceforthepreventionandcontrolofthedis
4、ease.MethodsAdescriptiveanalysiswasconductedthroughthesurveillancedataofHFMDinHefeiCityfrom2011to2015.Descriptiveepidemiologicalmethodsandchi-squareanalysiswereusedforstatisticalanalysis.Etiologicalinformationwasfrommonitoringandfieldinvestigation.StoolspecimenswereamplifiedwithRt-
5、PCRfromthestoolsamplesofHEMDpatients.Sequenceswereanalyzedwithbioinformaticssoftware.ResultsThemorbidityrateofHFMDfrom2011to2015was196.11/100000.ThepeakofincidencewasfromApriltoJune.Mostpatientswerechildrenunder5yearsold,andtheproportionofIIFMDinthiscrowdwasrespectively94.45%intota
6、lcases.Severecaseswouldbemorepossiblewhenthepatientswereinfectedbyenterovirus71.DatafromphylogeneticanalysisrevealedthatEV71isolatedfromHFMDpatientsinHefeibelongedtoC4aevolutionbranch.Theinfectionrateofhealthychildrennurserywas6.80%,allbelongingtootherenterovirusinfections.Conclusi
7、onTheprevalentlevelofHEMDishigheratpresentinHefeicity.ThemajoretiologicagentisEV71whichbelongstoC4aintheC4sub-genotypes.ItisnecessarytomakefocalpointofcontrollingHFMDinchildrenunder5yearsold.Keyword:Hand;footandmouthdisease;Epidemiologicalcharacteristics;Enterovirus71;Received:2017
8、-04-17手足口病(hand,footandmou
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