双手协同技能相关脑区的功能磁共振成像及半球优势研究

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1、汕头大学医学院硕士学位论文ABSTRACTBackgroundandObjectiveOurstudyusedBOLD-basedfMRI(functionalmagneticresonanceimagingbasedonbloodoxygenationlevel)toidentifytheneuralsubstratesofbimanualcoordination.Thebraindominanceforbimanualfingermovementswasalsoresearched.MethodsFifteenright-hand

2、edhealthyvolunteers(eightmaleandsevenfemale)werescannedataGyroscan1.5Teslamagneticresonanceimagingscanner(Philips)whiletheywereperformingbimanualfingermovementsofdifferentcharacteristics(mirrorsequentialfingermovementsorparallelsequentialfingermovements)attherateof1Hz.T

3、heexperimentconsistsof4runs.Everyrunconsistsoffourtask-blocks(12s)andfourrest-blocks(18s).Thetask-blockandrest-blockwerepresentedbyturns.Thetwodifferentbimanualfingermovements(mirrorsequentialfingermovementsorparallelsequentialfingermovements)werealsopresentedbyturnsdur

4、ingtask-blocks.Brainactivityunderlyingbimanualcoordinationcouldbedetectedbycontrastingthedifferentbrainactivationoftwokindsofbimanualfingermovements.Allsubjects’averagevalueofBOLDfMRIsignalchangesanditsactivationintensitywereindicatedwithfalsecolors,andcoveredtotheirrel

5、ativestructuralimages.ResultTheresultsshowedbothmirrorsequentialfingermovementsandparallelsequentialfingermovementsactivatedalargeareabilaterallycoveringtheprimarysensorimotorcortex(PSM),premotorarea(PMA),parietallobule(PAR),butmoreprominentlyintherighthemispherethanint

6、helefthemisphere.Besidesthisactivation,therightfrontallobe,thebilateralsupramargimlgyms,thebilateralsupplementarymotorarea(SMA),thebilateralcerebellumandbilateralbasalganglia(BG)arealsoactivated.Activationoftherightpremotorarea(PMA),bilateralparietallobule(PAR),andright

7、inferiorfrontalgyrusweresignificantlystrongerduringtheparallelsequentialfingermovementsthanduringthemirrorsequentialfingermovements.TherightIII汕头大学医学院硕士学位论文hemisphereandleftcerebellumseemedtobelargeractivatedthanthecontra-lateralbothduringtheparallelmovementsandduringth

8、emirrormovements.ConclusionsThus,wecaninferthattherightPMA,bilateralPAR,andrightinferiorfrontalgyrusappeartobe