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1、-摘要差异有统计学意义。5.HIF-1αmRNA在肾组织中的表达结果：K组和P组较之于C组，均明显增加（P<0.05）；P组较之于与K组，明显降低（P<0.05）；差异均有统计学意义。结论盐酸戊乙奎醚预先给药能够减轻内毒素血症时肾组织炎症反应，改善其组织病理学变化。对内毒素性肾损伤发挥肾保护作用的机制：可能是通过抑制HIF-1α在肾组织中的表达；也可能通过保护内毒素损伤情况下肾脏谷氨酰胺代谢途径，减少谷氨酰胺的消耗有关。关键词：内毒素血症；肾损伤；盐酸戊乙奎醚；缺氧诱导因子-1α；谷氨酰胺V----万方数据----Ab
2、stractEffectsofpenehyclidinehydrochloridepretreatmentinendotoxemiaofneonatalratsPostgraduateLijuanWangSupervisorLihuaJiangDepartmentofAnesthesiologyThethirdaffiliatedhospitalofZhengzhouUniversityAbstractNeonatalkidneyinjuryisoneofcommondiseasesinPICU，alsoisthele
3、adingcauseofdeathinPICU.Neonatalacutekidneyinjuryisverycommon,butthestudieswererelativelyfew.Deathcausedbyacutekidneyinjuryisverycommon,andinlaterperiodcancauserenalinsufficiencyeasier,especiallyinverylowbirthweight,andneonatewithotherdiseases.Inrecentyears,ther
4、esearchonneonatalacutekidneyinjurywasincreasing.Inthecaseoflowbloodvolume,avarietyofpathologicalconditionssuchasshock,infection,hypothermiacaneasycasekidneydamage,alsocancauseneonatalrenalinsufficiency.Themortalityofacuterenalfailurecausedbyendotoxinaccountsfora
5、bout70%.Atpresent,thepathologicalmechanismofendotoxininducedacuterenalfailurewaspoorlyunderstood.Lipopolysaccharide(LPS)frequentlyusedasendotoxin,widelyusedintheanimalduringthepreparationofendotoxindamagemodels.Endotoxinofkidneydamagecanleadrenalhemodynamicchang
6、es,makethebodyappearischemiaanoxic;Endotoxinofkidneydamagecanalsoleadtheoxidativemetabolismofthecellsdestroyed.Studieshaveshownthathypoxia-induciblefactor,astheregulationgeneintheanoxiccondition,canproducenucleoproteinundertheconditionofoxygennucleoprotein,combi
7、newithitstargetgenesandbringaboutachangeinadaptationtohypoxiaenvironmentcondition,thuscauseHIF-1aexpressionincreased.HIF-1αcanpromotethereleaseofinflammatorycytokinesthroughNF-kBsignalpathways,thusworsenkidneydamage.Otherstudiessuggestedthatglutamine(Gln)assubst
8、ratesofVI----万方数据----Abstractrenaldysplasiasugar,andasfuelofrenaltubularcelloxidativemetabolism.Endotoxemiaoccurs,Glncaninhibittheapoptosisofrenaltubularepithelialcel
