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1、-上海市交通大学医学院硕士生论文子肝素组中延长与丹参组及硫酸镁组比较均有统计学差异（P<0.05或P<0.01）。③D-D、F1+2、TXB2在低分子肝素组中下降最明显，且有统计学意义（P<0.05）。④BUN、CR、ALT、AST、LDH变化在硫酸镁组、丹参组、低分子肝素组无统计学差异（P>0.05）；UA在硫酸镁组中升高，在丹参组中下降，在低分子肝素组中下降更明显，低分子肝素组与硫酸镁组相比有统计学意义（P<0.05）。⑤24h尿蛋白在硫酸镁组中增加，在丹参组中轻度增加，在低分子肝素组中下降明显；低分子肝素组与硫酸镁组，丹参组相比均有统计学意义（P<0.05或P<0.01）。结论1.
2、FIB、D-D、F1+2、TXB2可以作为诊断妊娠期高血压疾病高凝状态及其严重程度的敏感指标，指导临床诊断及治疗。2.早发型子痫前期与晚发型子痫前期相比，高凝状态和凝血功能障碍更严重。3.低分子肝素治疗早发型重度子痫前期在抗凝血、抗继发型纤溶、抗血小板凝集，保护肾功能，减少尿蛋白方面均优于丹参；抗凝治疗在阻止妊娠期高血压疾病的进展上比单纯硫酸镁治疗有效。关键词：妊娠，高血压，子痫前期，凝血功能，低分子肝素，丹参---上海市交通大学医学院硕士生论文ASTUDYOFCOAGULATIONFUNCTIONOFHYPERTENSIVEDISORDERSINPREGANCYABSTRACTObje
3、ctive:1.Toanalyzethedifferenceofthecoagulationfunctionbetweenthethirdtrimesterofnormalpregnancywomenandthepatientswithhypertensivedisordersinpregnancy,thedifferencebetweenmildpreeclampsiaandseverepreeclampsia,andthedifferencebetweenearlyonsetpreeclampsiaandlateonsetpreeclampsia.2.Givethedifferent
4、anticoagulativetherapyonthepatientswithearlyonsetseverepreeclampsia;toanalyzethechangeofthecoagulationfunction,liverfunction,renalfunctionand24hurineproteinafterthetherapyoflow-molecular-weightheparin,salviamiltiorrhizaandmagnesiumsulfate;tocomparethedifferenceoftheabove-mentionedchangebetweenthe
5、therapyoflow-molecular-weightheparin,thetherapyofsalviamiltiorrhiza,andthetherapyofjustmagnesiumsulfate.Methods:1.Thebloodsampleswerecollectedfrom140normalpregnancywomenand76patientswithhypertensivedisordersinpregnancyfromAugust2005toJanuary2007inourhospital,respectively.HB,HCT,PLT,MPV,PT,APTT,FI
6、B,D-Dweretestedinthelaboratoryofourhospital;Prothrombinfragment1+2(F1+2),thromboxaneB2(TXB2)---上海市交通大学医学院硕士生论文weredetectedusingELISAmethodbymyself.2.Collect23patientswithearlyonsetseverepreeclampsiawhichwithoutseverecomplicationsfromAugust2005toJanuary2007,andgivethedifferentanticoagulativetherap
7、y,thetherapyoflow-molecular-weightheparin,thetherapyofsalviamiltiorrhiza,andthetherapyofjustmagnesiumsulfateascontrolgroup.Testthecoagulationfunction,liverfunction,renalfunctionand24hurineproteinbeforeandafterthetherap
