北大神经生物学课件2绪论

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1、Threshold(mA)ofafferentfibersactivatedbyEA(HANS)atdifferentfrequenciesAα012345672Hz0.6ms15Hz0.3ms100Hz0.2msTypesofnervefibers*Thresholdofexcitation(mA)AβAδCEffectofHANSonheartrateofheroinaddictsDayoftreatment1234567891060708090100110120130Control2Hz2/100Hz100Hzn=13-16

2、*********HeartRate(beat/min)BodyWeight(kg)01234567891011DaysofTreatment45505560Control2Hz2/100Hz100Hz(n=26-32)EffectofHANSonBodyWeightduringOpiateWithdrawal*************ThedoseofBPNneededbyHeroinAddictsduringdetoxificationBPNDose(mg/d)1234567891011121314DaysofTreatment

3、(n=14)0.00.51.01.52.02.5**********BuprenorphineHANS+BPN**P<0.001,comparedwithBPNgroupCRAVING:themostdifficultissue一朝吸毒，终身想毒。1Month050100RelapseRate(%)***P<0.05,comparedwithBPNgroup92%78%57%71%100%100%HANSDecreasesHeroinRelapseRateoftheHeroinaddicts2Month3MonthBPN(n=12)

4、HANS+BPN(n=14)*Theauto-trackconditionedplacepreference(CPP)instrumentMorphine-inducedconditionedplacepreference(CPP)Dose-dependenteffect*p<0.05,**p<0.01,***p<0.001;comparedwith0mg/kggroupIndexofpreference=TimeMor/(TimeMor+Timesaline)Morphine-inducedCPPLineardoseeffectr

5、elationship-2-1010100200n=9-12LgofMorDose(mg/kg)difference(s)EASuppressionofCPPforMorphineControlRestrainFootshockNeedle100Hz2Hz2/100Hz0.02.55.07.510.0******TimeSpentintheDrug-pairingSide(min)n=18~20EffectofEAofDifferentFrequenciesEffectofEAReversedbyNaloxonen=8~9Needl

6、e2/100Hz2Hz0.02.55.07.510.0******2/100Hz+NX(5mg/kg)2Hz+NX(1mg/kg)Reinstatementofmorphine’sCPPonratsbystressTimeSpentintheDrug-pairingSide(min)FadingofMorphine’sCPPwithTimeTimefromLastDrug-pairing(days)0.02.55.07.510.01357*******FootShock2Hz2Hz+0.02.55.07.510.0NX1mg/kgn

7、=12RelapseInducedbyIntermittentFootshock(9daysafterlastdrug-pairing)SalineMorphine(4mg/kg)n=12***Ordrugpriming100Hz应激引起复吸条件反射随时间而消退DaysofobservationSuppressionofheroincravingbyHANSinhumans人体心瘾观察及HANS抗心瘾作用Druguseover1year(aver4.6y);Detoxificationover1month;Male,Aver25y;

8、n=29-30Cravingscore(VAS)30minperdayPre-HANSHANS-treatingPost-HANS102030100Hz2HzMock2/100Hz0012345Norelapseover1yearCl