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1、氨氯地平与贝那普利联合治疗论文【摘要】目的观察氨氯地平与贝那普利联合治疗对原发性高血压患者蛋白尿的影响。方法选择高血压肾病患者86例,将患者分为:治疗组(Ⅰ组)43例,对照组(Ⅱ组)43例。治疗组同时给予苯磺酸氨氯地平5mg日一次口服，贝那普利80mg日一次口服;对照组给予降血压、保护心脏等一般治疗。治疗8周后观察血压、尿微量白蛋白（UAE）、甘油三酯(TG)、总胆固醇(TC)、血肌酐(SCr)、血尿素氮(BUN)等指标。结果治疗前，治疗组与对照组尿UAE无统计学差异；治疗后治疗组与对照组比较,治疗
2、组尿UAE显著降低(P0.01)。治疗组及对照组的血压、BUN、SCr、TC、TG等差异均无统计学意义。结论研究结果表明联合应用血管紧张素转换酶抑制剂贝那普利与钙离子拮抗剂氨氯地平在良好的控制血压同时可以显著降低高血压肾病早期的尿蛋白，达到保护肾脏的目的。【Abstract】ObjectiveOurgoalonlyusedcalciumchannelblocker,amlodipine,andanangiotensinconvertingenzymeinhibitor,Benazeprilonuri
3、naryalbuminexcretioninpatientsicroalbuminuria.These86patientsicroalbuminurialydividedintotentgroupreceiveamlodipineandbenazepril,thecontrolgroupreceivethegeneraltreatmentincludingcontrolbloodpressureandprotectingtheheart.S,etal.Prevalenceofmicroalbumin
4、uriainessentialhypertension:AstudyofpatientsildtomoderatehypertensionJ.IndianJNephrol(0971-4065),2001,11:6–112LositoA,FortunatiF,ZampiI,etal.ImpairedfunctionalreserveandalbuminuriainessentialhypertensionJ.BrMedJ(0007-1447),1988,1:1562–15643GiaconiS,Lev
5、antiC,FommeiE,etal.MicroalbuminuriaandcasualandambulatorybloodpressuremonitoringinnormotensivesandinpatientsildhypertensionJ.AmJHypertens(0895-7061),1989.2:259–2614MarreM,LeblaneH,SuarezL,etal.Convertingenzymeinhibitionandkidneyfunctioninnormotensivedi
6、abeticpatientsicroalbuminuriaJ.BMJ(0959-8138),1987,294:1448–14525ReamsGP,BauerJH.Effectofenalaprilinsubjectsoderatetosevererenaldysfunction.ArchInternMed.1986;146:2145–8.6.BauerJH,ReemsGP.Docalciumantagonistsprotectthehumanhypertensivekidney?JAmJHypert
7、ens(0895-7061),1989,2:173–1787BigazziR,BianchiS,CampeseVM,etal.PrevalenceofmocroalbuminuriainalargepopulationofpatientsildtomoderateessentialhypertensionJ.Nephron(0028-2766),1992,61:94–978GILBERTRE,COOPERME.Thetubulointerstitiuminprogressivediabetickid
8、neydisease:morethananaftermathofglomerularinjury?JKidneyInt(0085-2538,1999,56(5):1627-1637
