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1、StagingSoftTissueSara论文.freel,MBBS,DinaCheloucheLev,MD,AlexanderJ.F.Lazar,MD,PhDandRaphaelE.Pollock,MD,PhD【关键词】SaraDr.KotilingamisGraduateResearchAssistant,TheUniversityofTexasMDAndersonCancerCenter,Houston,TX.Dr.LevisAssistantProfessorinCancerBiology,TheUniversityofTexasMDAndersonCancerCenter,.free
2、lelyheterogeneousgroupofraretumorsthatshareaputativemesenchymalcellorigin.STScanoccurinanysofttissueinthebody,yetallshareamonfeatureofprimarilydisseminatinghematogenously,particularlytothelungs.StagingforSTSisparticularlyusefulinprognosis,designofeffectivemultimodalitytreatmentprograms,andparingtrea
3、tmentoutesfromdifferentcentersanddifferenteras.ThecurrentiterationofAJCCSTSstagingincludesTumor,Grade,Node,andMetastasisprovethisprocessexist,particularlyasmolecularconsiderationsbeemoreapparent,andfutureevolutionintoanevenmoreusefulSTSstagingsystemcanbeanticipated.INTRODUCTIONSofttissuesaraisanextr
4、emelyrareformofmalignancythatconstituteslessthan1%ofadultsolidmalignancy.Thereareapproximately9,530neorethan50separatehistologicsubtypes,manyoforemoncarcinomas,esenchymalderivationandcaninvolveconnectivetissuestructuresasentanyanbody.Approximatelytity,,abdomen,orotherlocations.Overallsurvivalisappro
5、ximately50%at5years;thekeydeterminantofsurvivaliscontrolofbothlocalrecurrenceasination.Dependingonstage,effectivetreatmentusuallyrequiressurgicalextirpationotherapy.STSdisseminatesprimarilyviathehematogenousroute,particularlytothelungs.Althoughdistantmetastasisisanominousfinding,theroleofmetastasect
6、omyinbinationentscontinuestoexpand,andpatientsinationhasbeensuccessfullyaddressedinthismanner.Unlikemanyothertypesofmalignancy,localrecurrenceisnotnecessarilyaharbingerofsoon-to-emergesystemicfailure.Indeed,themajorityofpatientsanydisease-freesurvivorship.Mostsofttissuesarashavenoclearlydefinedetiol
7、ogy,althoughmultipleassociatedorpredisposingfactorshavebeenidentified.Asutationsinpluripotentmesenchymalstemcellsarebelievedtogiverisetomalignantclones,ationofthesediseasetypes.Severalinheritedcancers
