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1、食管鳞癌组织COX论文逄小红，李效良，李跃，葛兆茹，吕伯实，安淑红【关键词】食管肿瘤Correlationbetphaticmetastasisinesophagealsquamouscarcinoma【Abstract】AIM:Toinvestigatethecorrelationoftheexpressionsofcyclooxygenase2(COX2)andvascularendothelialgroouscarcinomaandtheirimplicationintumorlymphaticmetastasis.METHODS:Theexpressionso
2、fCOX2andVEGFCinedbyimmunohistochemicalmethodin72casesofesophagealsquamouscarcinomaand24casesofnormalesophagealmucosa.RESULTS:ThepositiveratesofCOX2andVEGFCinesophagealsquamouscarcinomaalesophagealmucosa.TheexpressionsofCOX2andVEGFCorinvasionandlymphnodemetastasis(P0.01),butnotorsizeordi
3、fferentiation.TheexpressionofCOX2ayparticipateinVEGFClymphangiogenicpathportantroleinthelymphaticmetastasisofesophagealsquamouscarcinoma.【Keys;endothelialgrootoM,OkumuraH,etal.Prognosticfactorsinpatientsucosalesophagealcancer［J］.JGastrointestSurg,2004,8(5):631-635.［2］KomatsuS,Ichikaphat
4、icvesseldensityandvascularendothelialgroalignantbehaviorinhumanpancreaticendocrinetumors［J］.ClinCancerRes,2004,10(20):6919-6928.［4］JiaYT,LiZX,HeYT,etal.Expressionofvascularendothelialgrophangiogenesisandlymphaticmetastasisincolorectalcancer［J］.olMed,2004,14(3):389-395.［9］FujimotoJ,Toyok
5、iH,SatoE,etal.Clinicalimplicationofexpressionofvascularendothelialgroetastaticlymphnodesofuterinecervicalcancers［J］.BrJCancer,2004,91(3):466-469.［10］MurataH,Kaphaticinvasionandmetastasisinhumangastriccarcinoma［J］.AmJGastroenterol,1999,94(2):451-455.［11］KyzasPA,StefanouD,AgnantisNJ,etal.
6、COX2expressioncorrelatesphnodemetastasesinpatientsouscellcarcinoma［J］.ModPathol,2005,18(1):153-160.
