利拉鲁肽对体外成骨细胞增殖、分化、凋亡影响及其作用机制研究

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1、授予单位代码10089学号或申请号20151043中国图书分类号R589.5HebeiMedicalUniversity博士学位论文学术学位利拉鲁肽对体外成骨细胞增殖、分化、凋亡影响及其作用机制研究研究生：吴学伦导师：李玉坤教授专业：内科学二级学院：第三医院2018年4月河北医科大学目录中文摘要...........................................................................................................1英文摘要............................

2、...............................................................................7英文缩写.........................................................................................................14研究论文利拉鲁肽对体外成骨细胞增殖、分化、凋亡的影响及其作用机制研究引言.............................................................

3、.............................................17第一部分利拉鲁肽促进MC3T3-E1细胞增殖和分化前言..........................................................................................................21材料与方法.............................................................................................22结果....

4、......................................................................................................37附图..........................................................................................................40附表........................................................................

5、..................................44讨论..........................................................................................................46小结..........................................................................................................48参考文献............................

6、......................................................................49第二部分利拉鲁肽通过GLP-1R激活PI3K/Akt、ERK1/2和cAMP/PKA信号通路与β-catenin交联促进MC3T3-E1细胞增殖和分化前言..........................................................................................................54材料与方法..........................

7、....................................................................55结果..........................................................................................................63附图..........................................................................................