paes暴露的社会学特征及paes与血压的相关性分析

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1、授予单位代码10089学号或申请号20152146中国图书分类号R12HebeiMedicalUniversity硕士学位论文学术学位PAEs暴露的社会学特征及PAEs与血压的相关性分析研究生：樊彤彤导师：魏宁教授专业：社会医学与卫生事业管理二级学院：第三医院2018年3月目录中文摘要··············································································1英文摘要·····························

2、·················································3英文缩写··············································································6研究论文PAEs暴露的社会学特征及PAEs与血压的相关性分析前言··············································································8材料与方法······

3、·······························································10结果··············································································13附图··············································································17附表························

4、······················································18讨论··············································································27结论··············································································30参考文献·······························

5、·········································30综述邻苯二甲酸酯类暴露的生物学效应及相关机制·····················39致谢····················································································52个人简历···········································································

6、···53中文摘要PAEs暴露的社会学特征及PAEs与血压的相关性分析摘要目的：社会行为因素可能影响人群邻苯二甲酸酯（PAEs）的暴露水平，但是相关研究较少。本研究拟对二者的相关性进行分析，探寻影响PAEs暴露水平的社会行为因素。PAEs暴露可引起动物血压发生改变，然而人群流行病学的研究结论并不一致。因此，在获取人群PAEs暴露水平的数据后，进一步分析其与血压改变的相关性，为PAEs暴露致人体健康的损伤效应提供流行病学依据。方法：于2014年12月至2015年9月间，以河北省某三甲医院的体检人群作为研究对

7、象，共选取18-55周岁健康成人609名。通过调查问卷收集一般人口学资料（年龄、性别等）、个人行为（吸烟、饮酒等行为）、饮食习惯（豆类、蛋类等食物的摄入习惯）、健康状况等信息。以内标法检测血清中常见的16种PAEs暴露水平。血压等效应指标（收缩压、舒张压、总胆固醇、甘油三酯）的数据来自于体检结果。采用多元线性回归分析影响PAEs暴露水平的社会行为因素，同时对PAEs暴露水平与血压等指标的相关性进行分析。结果：1.16种PAE单体中，邻苯二甲酸二正丁酯（DBP）的检测率最高，为100%，其次是邻苯二甲酸二异

8、丁酯（DIBP）和邻苯二甲酸二甲酯（DMP），检出率分别为89.7%和79.8%，邻苯二甲酸二（4-甲基-2-戊基）酯（BMPP）、邻苯二甲酸二正辛酯（DNOP）和邻苯二甲酸（2-乙基己基）酯（DEHP）三者的检出率介于60%至80%之间，其余PAEs的检出率均在60%以下。最高检出率的6种PAEs浓度的几何均值分别为253.9ug/L、40.7ug/L、10.8ug/L、9.4ug/L、33.9ug/L和97.4ug/L。2