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1、<文献翻译：原文>Synthesis,characterizationandcytotoxicitystudiesofchitosan-coatedteapolyphenolsnanoparticlesabstract：Chitosannanoparticles(CS-NPs)werepreparedbyionicgelationmethodusingcarboxymethylchitosanandchitosanhydrochlorideascarriersofteapolyphenols.Thecharacteristicsofchi
2、tosan-coatedteapolyphenolsnanoparticles(CS-TPNPs)weredeterminedbyusingtransmissionelectronmicroscopy(TEM)andFT-IRspectroscopy.ItwasfoundthatthesynthesizedCS-TPNPswerenon-sphericalinshapewithanaveragesizeof407±50nm.Meanwhile,thedrugcontentandencapsulationrateofthenanoparti
3、cleswas8–16%and44–83%,respectively.TheseCS-TPNPsalsodemonstratedsustainedreleaseofteapolyphenolsinPBS.TheantitumorofCS-TPNPstowardsHepG2cancercellswasinvestigated.TheresultshowedthatCS-TPNPsretainedsignificantantitumoractivities.1.IntroductionNowadays,canceristhemajorpubl
4、ichealthproblemandtheexistingtreatmentapproachesandsurgicaltechniqueshavenotbeenabletocopeeffectivelywiththisdreadeddisease.Becauseofthis,chemopreventionisavalidapproachtoreducetheincidenceofcancer[1].Asaneffectivecancerchemopreventiveagent,teapolyphenolsareknowntobestron
5、gantioxidantsandanticarcinogenicactivities[2].Invitroandanimalstudiesprovidestrongevidencethatpolyphenolsderivedfromteamaypossessthebioactivitytoinhibittumorigenesisinavarietyofanimalmodelsofcarcinogenesis[3].Teapolyphenolshasbeenshowntoinhibitthedevelopmentofcancerinanim
6、almodelsoforal,esophageal,forestomach,stomach,intestinal,colon,skin,liver,bladder,prostate,andbreastcancer[4,5].Althoughteapolyphenolsarewidelyusedforthepreventionandtreatmentofcancer,itstherapeuticeffectsarealwayslimitedbysevereadverseeffects,suchasthestabilityofbiologic
7、alactivityintissueandbioavailabilityinvivo,etc.[6].Therehavebeenreportedthatthebiologicalactivityofteapolyphenolsmightdependontheformoftheiradministration[7].Toovercomethesedisadvantagesandimprovechemotherapeuticactivity,researchershavefocusedonthedevelopmentofnano-sizedd
8、rugcarriers[8–10].Nanoparticles,withhighlycon-trolledshapes,sizes,havebeenstudiedextensivelyasdr
