甲状腺球蛋白在分化型甲状腺癌诊疗过程中的临床价值

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1、授予单位代码10089学号或申请号20153422中国图书分类号R246.81HebeiMedicalUniversity硕士学位论文专业学位甲状腺球蛋白在分化型甲状腺癌诊疗过程中的临床价值研究生：杨一卿导师：赵瑞力教授专业：耳鼻咽喉科学二级学院：第四医院2018年3月目录中文摘要·················································································1英文摘要··········································

2、······································2英文缩写···············································································3综述甲状腺球蛋白在分化型甲状腺癌诊疗过程中的临床价值············4致谢····················································································23个人简历···············

3、································································24中文摘要甲状腺球蛋白在分化型甲状腺癌诊疗过程中的临床价值摘要归纳总结近年来甲状腺球蛋白（Tg）在分化型甲状腺癌（DTC）诊疗过程中临床意义的相关研究文献，就Tg在DTC的术前诊断、术后评估及后续治疗中的临床价值进行综述。以关键词“Differentiatedthyroidcancer（DTC），thyroglobulin（Tg），thyroglobulinantibody（TgAb），Prognosis

4、,recurrence,benign,malignant”通过Pumbed，SCI，Ovid等文献库进行文献检索，搜集整理相关数据并总结归纳。得出结论：1.术前血清Tg不能作为诊断肿瘤良恶性的标准，但可能与恶性肿瘤存在风险正相关。2.对于全切术后及碘消融治疗后的DTC患者，Tg可作为DTC复发或转移高度敏感和可靠的指标。对于未行甲状腺全切的DTC患者，Tg对于术后复发或转移的临床意义尚存在争议。3.针吸液中的Tg（FNA-Tg）的测量是检测DTC颈部复发转移较为准确的工具。4.刺激性甲状腺球蛋白（sTg）可用于指导放射性碘（RAI）

5、治疗。关键词：分化型甲状腺癌，甲状腺球蛋白，甲状腺球蛋白抗体，预后，复发，良性，恶性1英文摘要TheclinicalvalueofTginthediagnosisandtreatmentofDTCABSTRACTToreviewtheclinicalsignificanceofthyroglobulin(Tg)inthediagnosisandtreatmentofdifferentiatedthyroidcancer(DTC)inrecentyears.Usingthekeywords,"Differentiatedthyroid

6、cancer(DTC),thyroglobulin(Tg),thyroglobulinantibody(TgAb),Prognosis,recurrence,benign,malignant",tosearchliteraturesbyusingthelibraryofPumbed,sci,Ovid,etc.Conclusion:1.AlthoughpreoperativeTglevelsarenotassociatedwithadiagnosisofcancer,theyareassociatedwiththepresenceof

7、metastaticdisease.2.Aftertotalthyroidectomyand131Iablationofresidualnormalglanditcanbeusedasahighlysensitiveandreliablemarkerofrecurrenceormetastasisindifferentiatedthyroidcancer(DTC);andtheclinicalvallueofTginDTCpatientswithouttotalthyroidectomyforpostoperativerecurre

8、nceormetastasisisstillchallenge.3.Thyroglobulinmeasurementinneedleaspirationwashoutfluids(FNA-Tg)measurementisthemore