支气管肺泡灌洗液肿瘤标志物检测对肺癌诊断的临床意义

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1、目录中文摘要··········································································································1英文摘要····································································································3英文缩写···································································

2、·········································6研究论文支气管肺泡灌洗液肿瘤标志物对肺癌诊断的临床意义前言··········································································································7材料与方法····························································································9结果···········

3、······················································································14附表··································································································16讨论·································································································

4、·····20结论······································································································24参考文献·······························································································24综述肺癌的诊断进展··································································

5、··············30致谢··············································································································40个人简历····································································································41支气管肺泡灌洗液肿瘤标志物检测对肺癌诊断的临床意义摘要目的：本研究通过检测血清及支气管肺泡灌洗液中癌胚抗原

6、(CEA)、神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)、胃泌素释放肽前体(ProGRP)的含量来探讨其与肺癌之间的关系，以期对肺癌的早期诊断能有指导价值。方法：采用病例-对照研究方法，收集病例组：经病理确诊的肺癌患者55例，男性35例，女性20例；对照组：确诊肺良性病变患者共23例，其中男性13例，女性10例，均采用ELISA的方法对纳入患者检测其血清及肺泡灌洗液中CEA、NSE、CYFRA21-1、ProGRP的含量，并测定不同分期、不同组织类型中四种标志物的变化，观察其对肺癌诊断的临床意义。结果：1.肺癌组中，肺泡灌洗液CEA含量(62.

7、7±25.48)显著高于血清CEA含量(33.6±10.42)，P=0.001；灌洗液CYFRA21-1含量(45.16±16.01)显著高于血清CYFRA21-1含量(17.18±9.31)，P=0.001；同样，灌洗液ProGRP含量(150.19±43.26)明显高于血清ProGRP含量(72.53±45.16)，P=0.001。虽然灌洗液NSE含量(47.83±17.09)高于血清NSE含量(25.87±8.76)，但无统计学差异，P=0.053。2.肺良性病变组中，肺泡灌洗液CEA含量(7.1±3.89)与血清CEA