屈光参差性弱视患者视网膜结构与功能变化的研究

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1、授予单位代码10089学号或申请号16145中国图书分类号R777.4HebeiMedicalUniversity硕士学位论文学术学位屈光参差性弱视患者视网膜结构与功能变化的研究研究生：张丹导师：柴松副教授专业：眼科学二级学院：第二医院2018年3月目录中文摘要················································································1英文摘要···························································

2、······················3英文缩写·················································································5研究论文屈光参差性弱视患者视网膜结构与功能变化的研究前言·················································································6材料与方法···················································

3、·····················6结果·················································································9附图···············································································12附表···············································································14讨论·

4、··············································································20结论·············································································24参考文献...........................................................................25综述弱视的诊断和治疗.......................

5、...................................28致谢......................................................................................37个人简历..............................................................................38屈光参差性弱视患者视网膜结构与功能变化的研究摘要目的：使用图形视觉诱发电位（PatternVisualEvokedPotenti

6、al，P-VEP）和光学相干断层扫描（OpticalCoherenceTomography，OCT）检查技术，研究屈光参差性弱视患者视力恢复正常后视网膜结构的改变及功能的恢复。方法：回顾性研究。收集2016年12月-2017年3月于保定市第二中心医院眼科门诊就诊的由于屈光参差所致的弱视患者，共46例，其中男性患者26例，女性患者20例。再按年龄分为6-12岁组（27人）和大于12岁组（19人）两个自然队列。研究对象入选后，检查的内容和方法包括以下几项：视力、屈光度检查、眼轴测定、P-VEP和OCT测定。并采取综合治疗的方法对弱视患者进行治疗，观

7、察1年后其弱视恢复情况以及相关指标的变化情况，和两个队列之间的差异。结果：1.6-12岁组和大于12岁组，弱视眼的视力、等效屈光度无差异，6-12岁组眼轴长度偏短，差异有统计学意义（P=0.000）。治疗1年后，6-12岁组的基本治愈率59.26%高于大于12岁组的治愈率31.58%，6-12岁组的疗效比大于12岁组好，差异有统计学意义（P=0.021）。2.治疗前，大于12岁组和6-12岁组的弱视眼相比，P100波潜伏期延迟，振幅降低；两组患者弱视眼和对侧眼相比，P100波潜伏期延迟，同时大于12岁组的振幅降低。6-12岁组和大于12岁组相比

8、，弱视眼黄斑区平均RNFLT偏薄；大于12岁组弱视眼与对侧眼相比，黄斑区RNFLT在颞侧区域偏厚。3.基本痊愈患者，弱视眼治愈后与治疗前相比，6-12