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1、黄芪总皂苷和姜黄素不同配比组分对大、小鼠糖尿病模型的干预作用2英文摘要StudyontheinterventionofdistributionratioofAstragalosideandCurcuminonDMmodelofmiceandratsLiangxue(pharmacology)DirectedbyMiaomingsanAbstractObjective:Tostudytheeffectsofthedifferentactive-constituentproportionofAstragalosideandCurcuminonDi
2、abetesMellitusmodelofmiceandDiabetesMellitusmodelofratsbybaselinedesigncomparesincreaseordecrease.Toenrichtheinterventionofthedifferentactive-constituentproportionofchinesemedicinetotreatDiabetesMellitus,screenouttheoptimalactiveconstituentproportion,layingthefoundationfort
3、hesubsequentresearchonAstragaloside-Curcumincapsule.Methods:BythemethodofBaselineDesignComparesIncreaseorDecrease,Tostudytheeffectsofthedifferentactive-constituentproportionofAstragalosideandCurcuminin10:0、8:2、7:3、6:4、5:5、4:6、3:7、2:8、0:10onDiabetesMellitusmodelofmiceandrats
4、.UsingComprehensiveWeightmethodtoevaluatetheactive-constituentproportionofAstragalosideandCurcuminonDMmodelofmiceandrats,screeningouttheoptimalproportion.EstablishDiabetesMellitusmodelofmicebytailveininjectionofstreptozotocin,discusstheinfluenceofdifferentactive-constituent
5、proportionofAstragalosideandCurcuminonbloodsugar,glycosylatedserumproteins,hepaticglycogen,insulin,andobservingpancreaspathologicchangesinDMmodelofmice;EstablishDiabetesMellitusmodelofratsbyhypogloeeisveininjectionofstreptozotocin,.discusstheinfluenceofdifferentactive-const
6、ituentproportionofAstragalosideandCurcuminonbloodsugar,glycosylatedserumproteins,insulin,insulinantibody,leptin,triglyceride,cholesterol,high-densitylipoprotein,low-densitylipoprotein,methyl-di-aide-hyde,superoxidedismutase,andpancreasandkidneyofmodelmicebytestingbloodsugar
7、,glycosylatedserumproteins,insulin,insulinantibody,leptin,triglyceride,cholesterol,high-densitylipoprotein,low-densitylipoprotein,Lipidperoxides,superoxidedismutase,andobservingthepathologicalchangesofpancreaticisletβ-cellandrenalinjuryinDMmodelofrats.Results:Theratsandmice
8、DMmodelswerereproducedsuccessfully.Comparedwith3黄芪总皂苷与姜黄素不同配比组分对大、小鼠糖尿病模型的干预作用them
