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1、CapecitabineMonotherapy【关键词】Capecitabine,#8226;,Breast,cancer,#8226;,Single,agent,#8226;,Monotherapy,#8226;,Efficacy,#8226;,Safety,#8226;,Quality,of,life LEARNINGOBJECTIVES Afterpletingthiscourse,thereaderacologyofcapecitabine. Discusstheuseofcapecitabineasasin
2、gleagentandinrefractorydisease. Discusssafetyanddosingconsiderations Describecurrentadjuvanttreatmentalmanagementformetastaticbreastcancerfrequentlyinvolvescytotoxicchemotherapy.Overtheyears,severalplexmultidrugregimenshavebeendevelopedthatoractivityandnonoverla
3、ppingtoxicities.Hoenshasbeencalledintoquestionasseveraldrugsusedalone(monotherapy)orinsequence(serialsingleagent)havebeenshoinisteredfluoropyrimidinecarbamate)isonesuchagentthathasbeenproventobeeffectiveetastaticbreastcancer,metastaticcolorectalcancer,andadjuvantc
4、oloncancer.Inthisrevie)dataexaminingvariousaspectsofclinicalresponseandtolerabilityarily)first-andsecond-linemetastaticbreastcancerareexamined.Forthemostpart,responseratesareparableoreplexregimens.Dosereductionsfromthelabeleddoseof1,250mg/m2ton.Toxicities(folloana
5、geable,evenbymorefrailpatients.Elderlypatientsaremorelikelytohaveimpairedrenalfunctionorbereceivingent,andspecialattentiontothesefactorsisinisteredaloneisareasonablechoiceotherapyisentertainedasatreatmentoptionformetastaticbreastcancer,includinginthefirst-linesett
6、ing. INTRODUCTION Breastcanceristhemostfrequentlydiagnosedcancerinenandthesecondleadingcauseofcancer-relateddeaths(follo98%inlocalizeddiseaseto80%etastaticdisease.Chemotherapyplaysanimportantroleinbreastcancer,etastaticsetting.Singlechemotherapeuticagentsinclude
7、dintheNationalprehensiveCancerNetaldoxorubicin),taxanes(e.g.,paclitaxel,docetaxel),vinorelbine,andcapecitabine,eachofaybeusedasasingleagent6789101112131415forrecurrentormetastaticdisease[2].Amongthetaxanes,forexample,single-agentpaclitaxelhasbeenshootherapy-na&ium
8、l;ve)patientsetastaticdisease,yieldingresponseratesof25%34%[35],etastaticsettings,otherapy-naïvepatients[9]and17%23%inpatientsotherapy[1012].Contin