胰酶肠溶片联合枳术宽中胶囊治疗功能性消化不良

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1、胰酶肠溶片联合枳术宽中胶囊治疗功能性消化不良常廷民范颖英李贞娟(新乡医学院第一附属医院消化内科河南卫辉453100)【中图分类号】R571【文献标识码】A【文章编号】1672-5085(2011)40-0088-03【摘要】目的评价胰酶肠溶片联合枳术宽中胶囊在治疗功能性消化不良中的临床疗效和安全性。方法将消化内科门诊中被确诊为功能性消化不良的90例患者随机分成A、B、C3组，每组30人，A组口服胰酶肠溶片和枳术宽中胶囊，B组单口服枳术宽中胶囊，C组单口服胰酶肠溶片，疗程均为2周，比较各组治疗前后上腹胀、痛、早饱、嗳气临床症状改善情况

2、并进行评分及治疗后临床症状消失时间。结果治疗后3组患者的临床症状积分均显著低于治疗前(P<0.01或P<0.05);B、C组患者治疗后临床症状改善率显著低于A组(P<0.01或P<0.05)；A组沿疗临床症状改善总有效率达到96%，均显著高于B、C组(P<0.05);B、C组临床症状消失时间明显长于A组，差异有统计学意义(P<0.05)o结论胰酶肠溶片联合枳术宽中胶囊治疗功能性消化不良起效更快，疗效更佳，安全性好，值得临床推广。【关键词】胰酶肠溶片枳术宽中胶囊功能性消化不良TheTreatment

3、ofFunctionalDyspepsia(FD)UsingPancreatinEnteric-coatedTabletcombineZhizhukuanzhongCapsule.[Abstract]Objective：ToevaluatetheclinicalefficacyandsafetyoftreatingfunctionaldyspepsiausingPancreatinEnteric-coatedtabletcombineZhizhukuanzhongcapsule.Methods：90patientsDiagnosed

4、withFDindigestionmedicineotpatientwererandomlydividedintoA,BandCthreegroups,eachgrouphad30people.GrouptookorallythePancreatinEnteric-coatedtabletandZhizhukuanzhongcapsule,groupBtookZhizhukuanzhongcapsuleonly,andgroupCtookPancreatinEnteric-coatedtabletonly,thecourseoftr

5、eatmentis2weeks,comparedthescoreandimprovementofsymptomlikeupperabdominaldistention,pain,earlysatiety,blechingetcandthetimethatclinicalsymptomsdisappearaftertreatment.Results:Aftertreatment,thesymptomscoresofthethreegroupsweresignificantlylowerthanbefore(p<O.OlorP&l

6、t;0.05);ThesymptomsimprovementrateingroupBandCweresignificantlylowerthangroupAaftertreatment(P<0.05);ThetotaleffectiverateingroupAreached96%aftertreatment,higherthangroupBandCsignificantly(P<O.O5);ThedisappearedtimeofsymptomsingroupBandCissignificantlylongerthang

7、roupA.Thedifferencehavestatisticalsignificance(p<0.05).Conclution:PancreatinEnteric-coatedTabletsjointoperationofZhizhukuanzhongCapsuleshaspositivecurativeeffectandhighersafetyinthetreatmentoffunctionaldyspepsia,andisworthwhileforspreadinginclinical.【Keywords］Pancre

8、atinEnteric-coatedtabletZhizhukuanzhongcapsulefunctionaldyspesia功能性消化不良(FD)是常见的消化系统疾病之一，欧美的流行病学调査表明，普通人群中有消化不良症状者占19%