探讨腹腔灌注化疗加静脉化疗与静脉化疗治疗中晚期卵巢癌临床效果

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1、探讨腹腔灌注化疗加静脉化疗与静脉化疗治疗中晚期卵巢癌临床效果望奎县人民医院152100【摘要】目的对比分析顺铂腹腔灌注联合多西紫杉醇加顺铂静脉化疗双途径治疗与顺铂联合多西紫杉醇单纯静脉化疗治疗晚期卵巢癌的临床疗效、不良反应。方法此次研究的对象是选择屮晚期卵巢癌患者42例，将其临床资料进行回顾性分析，并随机分为治疗组A组：顺铂腹腔灌注联合多西紫杉醇加顺铂静脉化疗双途径治疗)20例，对照组B组：顺铂联合多西紫杉醇单纯静脉化疗22例。结果治疗组有效率82.14%(23/28),对照组有效率70.37%(19/27),两组比较，差异有显著性(P&l

2、t;0.05)。全身毒性反应主要为消化道反应、肾毒性、血液学毒性和神经毒性，全身毒性反应治疗组较对照组略低；而局部毒性主要有腹痛、化学性腹膜炎和腹腔粘连，局部毒性反应治疗组较对照组略高。组间比较差异无显著性(P>0.05)o结论治疗组较对照组治疗晚期卵巢癌疗效更高，毒性反应可以耐受，腹腔化疗应用于屮晚期卵巢癌是一种安全而有效的的治疗模式,患者有较好的耐受性。【关键词】卵巢癌；腹腔灌注化疗；静脉化疗；多西紫杉醇；顺铂Abstract：ObjectiveTocomparetheclinicalefficacyofcisplatincomb

3、inedwithdocetaxelpluscisplatinandintravenouschemotherapywithcisplatinplusdocetaxeltreatmentdoublewayintravenouschemotherapyinthetreatmentofadvancedovariancanceradversereaction.Theobjectofthisresearchmethodistoselecttheadvancedovariancancerpatientsin42cases，theclinicaldataw

4、ereretrospectivelyanalyzed，andrandomlydividedintotreatmentgroupAgroup：intraperitonealcisplatincombinedwithdocetaxelpluscisplatinchemotherapytreatmentin20cases,doubleway)groupB：cisplatincombinedwithdocetaxelintravenouschemotherapyin22cases.Resultstheeffectiverateofthetreatm

5、entgroupwas82.14%(23/28)，thecontrolgroupwas70.37%(19/27)，thedifferencewassignificant(P<0.05)，thedifferencewassignificant().Allthemaintoxicitiesweregastrointestinalreactions,renaltoxicity，hematologictoxicityandneurotoxicity,systemictoxicityintreatmentgroupthaninthecontro

6、lgroupisslightlylower;andlocaltoxicitymainlyincludeabdominalpain，chemicalperitonitisandperitonealadhesion，localtoxicityslightlyhigherintreatmentgroupthaninthecontrolgroup.Therewerenosignificantdifferencebetweenthem(P>0.05).Conclusionthecurativeeffectofthetreatmentgroupt

7、hanthecontrolgroupinthetreatmentofadvancedovariancancerhighertoxicityofintraperitonealchemotherapyinadvancedovariancancerisasafeandeffectivetreatment,patientsarewelltolerated.Keywords：ovariancancer;intraperitonealchemotherapy;intravenouschemotherapy;docetaxel;cisplatin卵巢恶性

8、肿瘤为女性生殖系统三人恶性肿瘤之一，其发病率居妇科恶性肿瘤的第二位，【1】死亡率高居首位。早期无明显症状，超过75%的患者在就诊吋已有腹腔内广泛转移。B前对卵巢癌的治疗主要包括两