伊班膦酸钠和帕米膦酸二钠治疗骨转移癌疼痛的临床观察

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1、伊班膦酸钠和帕米膦酸二钠治疗骨转移癌疼痛的临床观察杨钰贤江艺林丹霞方玫玫郑瑾陈志明(汕头大学医学院附属肿瘤医院肿瘤内科广东汕头515031)【摘要】目的评价伊班膦酸钠和帕米膦酸二钠治疗骨转移癌疼痛的临床疗效和安全性。方法62例患者随机分为伊班膦酸钠组和帕米膦酸二钠组各31例，伊斑膦酸钠组给予伊班膦酸钠治疗，帕米膦酸二钠组给予帕米膦酸二钠治疗，2组均用药2〜6个周期。观察2组用药后止痛效果、骨修复、活动能力及不良反应发生情况。结果用药第14天时伊班膦酸钠组临床获益率为87.1%高于帕米膦酸二钠组的64.5%,差异有统计学意义(P<0.05);治疗56d伊班膦酸钠组临床获益率为90.

2、3%,帕米膦酸二钠组为83.8%，差异无统计学意义(P>0.05)。2组主要不良反应主要为发热、乏力，严重程度与骨质损害呈相关。结论伊班膦酸钠治疗骨转移癌疼痛疗效略优于帕米膦酸二钠，两者不良反应均较轻，均有良好的耐受性，值得临床推广应用。【关键词】伊班磷酸钠帕米膦酸二钠骨转移癌疗效【中图分类号】R969.4【文献标识码】A【文章编号】1672-5085(2014)08-0071-02ClinicalobservationofIbandronateandPamidronateinTreatmentofPainCausedbyBoneMetastasisYANGYu-xian,JIA

3、NGYi,UNDan-xia,FANGMei-mei,ZHENG-Jin,CHENZhi-ming(Dept.ofOncology,TumorHospitalofShantouUniversityMedicalCollege,ShantouGuangdong515031,China)【Abstract】ObjectiveToevaluatetheclinicaltherapeuticeffectandsafenessofibandronateandpamidronateintreatingpaincausedbybonemetastasis-Methods62caseswererand

4、omlydividedintoibandronategroupandpamidronategroup，31casesofeach.Theibandronategroupwastreatedwithibandronate，whilethepamidronategroupwastreatedwith.Bothgroupsweretreatedfor2to6cylces.Observed2group’sodynolysiseffect，situationsofbonereparation,activityabilityandadversereaction•ResultsOnthe

5、14thdayofadministration,theclinicalbenefitrateofibandronategroupwas87.1%higherthan64.5%ofthepamidronategroup，andthedifferencewasstatisticallysignificant(P<0.05).Onthe56thdayofadministration,theclinicalbenefitrateofibandronategroupwas90.3%higherthan83.8%ofthepamidronategroup，andthedifferencewa

6、sofnostatisticalsignificance(P>0.05)-Themainadversereactionsof2groupswerefewerandweakness,andtheseverityhadpositivecorrelationwithbonedamage.ConclusionIbandronatehasgoodcurativeeffectsabovepamidronateintreatingpaincausedbybonemetastasis.Bothofthetwodrugshasslightadversereactionandgoodtoleranc

7、e.Whichareworthclinicalpopularizingandapplication.【Keywords】IbandronatePamidronateBonemetastasisEfficacy骨骼是癌症转移的常见部位。骨转移所致的疼痛，多数是持续性剧烈疼痛,甚至发生病理性骨折，严重影响患者生存质量。临床上治疗骨转移癌疼痛的主要药物为双膦酸盐类药物。我院内科自2010年1月至2014年2月随机应用伊班膦酸钠(河北医科人学生物医学工