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1、脑血管介入术前给予阿托伐他汀强化治疗对肾脏功能的影响研宄张波(遂宁市屮心医院神经内科629000)【摘要】目的：研宂脑血管介入术前给予阿托伐他汀强化治疗对肾脏功能的影响。方法：抽选2013年8月〜2014年8月在我院神内科接受脑血管介入术治疗的患者98例，随机数字表法分为对照组(n=49)和观察组(n=49),观察组术前3天给予阿托伐他汀钙片80mg/天睡前顿服，术后持续给药40mg/天睡前顿服。检测对比两组患者术前、后Scr、Ccr、β2-MG、Cys-C、hs-CRP水平。结果：两组患者治疗前各指标比较无统计学差异(P>
2、0.05)；对照组治疗后Scr,β2-MG,Cys-C,hs-CRP水平较治疗前升高，Ccr较治疗前下降，差异均有统计学意义(P<0.05);观察组治疗后Cys-C较治疗前升高，差异有统计学意义(P<0.05)；观察组治疗后Scr,Ccr,β2-MG,Cys-C,hs-CRP水平与对照组比较差异显著，有统计学意义(P<0.05)。结论：脑血管介入术前给予阿托伐他汀强化治疗能有效保护患者肾脏功能，减少肾损害，值得推广。【关键词】脑血管介入术；阿托伐他汀；肾脏功能【屮图分类号】R453【文献标识码】A【文章
3、编号】2095-1752(2015)34-0149-02EffectofatorvastatinintensivetherapyonrenalfunctionbeforecerebrovascularinterventionaloperationZhangBo.Departmentofinternalmedicine,SuiningCentralHospitalSuining629000[Abstract]ObjectiveTostudytheeffectofatorvastatinintensivetherapyonrenalfuncti
4、onbeforecerebrovascularinterventionaloperation.Methods98patientswhoreceivedcerebrovascularinterventionaloperationintheneurologydepartmentduringAugust2013toAugust2014wereselectedanddividedintothecontrolgroup(n=49)andtheobservationgroup(n=49)accordingtotherandomnumbertableme
5、thod.3daysbeforeoperation,thecontrolgroupwasgivenatorvastatincalciumtabletsadministeredonceorallybeforegoingtobed,20mgperdaywhiletheobservationgroupwasgivenatorvastatincalciumtabletsadministeredonceorallybeforegoingtobed,80mgperdayandafteroperation,sustainedadministrationw
6、asgiven,40mgperdayonceorallybeforegoingtobed.ThelevelsofScr,Ccr,β2-MG,Cys-Candhs-CRPweredetectedandcomparedbetweenthetwogroupsbeforeandafteroperation.ResultsTherewasnostatisticaldifferenceinthecomparisonoftheindexesbetweenthetwogroupsbeforeoperation(P>0.05).Afterth
7、etreatment,levelsofScr,β2-MG,Cys-Candhs-CRPinthecontrolgroupwerehigherthanbeforethetreatmentwhileCcrwasshorterthanthatbeforethetreatment.Thedifferenceswerestatisticallysignificant(P<O.O5).Afterthetreatment,Cys-Cintheobservationwashigherthanthatbeforethetreatmentand
8、thedifferencewasstatisticallysignificant(P<0.05).ThedifferencesinlevelsofScr,Ccr,&beta
