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1、广州医学院硕士论文重度子痫前期与ERAP2基因多态性的相关性及血清中IL-32在其发病机制中的作用betweenpreeclampsiaandnormalcontrolsisT.②Whenanalysingrs17408150,wefoundathirdSNP36bpaway,namelyrs1423568,theERAP2rs1423568allelefrequenciesforC%andT%were37.14%and62.86%inpatientswithpreeclampsia,and36.59%and
2、63.41%innormalpregnancies,respectively.χ2=0.003，P=0.960，OR=1.024，95%CI0.402-2.609.③theERAP2rs2548672allelefrequenciesforT%andG%were37.14%and62.86%inpatientswithpreeclampsia,and34.15%and65.85%innormalpregnancies,respectively.χ2=0.74，P=0.786，OR=1.140，95%CI0.4
3、44-2.922.ConclusionOurworkdoesnotprovideevidenceinfavorofERAP2SNP(rs2549782,rs1423568,rs17408150)beingassociatedwithpreeclampsiaandnormalpregnantwomeninaChinesehanpopulation.【Keywords】preeclampsia,polymorphism,ERAP2PartⅡThestudyofIL-32inserumofseverepreecla
4、mpsiaandcontrols【Abstract】ObjectiveThepurposeofthepresentstudywastoinvestigatethechangesinplasmamarkersofIL-32inpreeclampsiaandtoevaluatetheirclinicalsignificanceandinteractionsinthepathogenesisofpreeclampsia.MethodsAcase-controlstudywasconductedinvolving39
5、womenwithpreeclampsia(studygroup)and40normotensivepregnantwomen(controlgroup)inthethirdtrimester.Theplasmaconcentrationsofinterleukin-32(IL-6)weredetermined.ResultsTheplasmacomcentrationsofIL-32wassignificantlyhigherinthestudygroup(789.07±167.70ug/L)thantho
6、seofthecontrol(520.42±143.65ug/L)(P<0.01,orP<0.05)Conclusion①IL-32mayplayaroleinthepathogenesisofPE.②ThedetectionofserumlevelsofIL-32inpreeclampsiamayprovideanewwayforearlydetectionandtreatment.③theserumlevelsofIL-32isassociatedwiththeparticularsofthediseas
7、e.WhentheserumlevelofIL-32increas,TNF-αisinduecd,causingfurtherendothelialcellinjuryof7广州医学院硕士论文重度子痫前期与ERAP2基因多态性的相关性及血清中IL-32在其发病机制中的作用preeclampsia.【Keywords】Interleukin-32;tumornecrosisfactor-α;vascularendothelialcelldysfunction;inflammation;pregnancy-ind
8、ucedhypertension;pre-eclampsia8广州医学院硕士论文重度子痫前期与ERAP2基因多态性的相关性及血清中IL-32在其发病机制中的作用主要符号表缩写英文中文ERAP2endoplasmicreticulumaminopeptidase2内质网氨肽酶2MTHFR5,10-methylenetetrahydrofolatereductaseN5,N10亚甲基四氢叶酸还(NADP
