他克莫司治疗原发性肾病综合征的临床分析

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1、［摘要］目的探讨他克莫司治疗原发性肾病综合征的临床疗效情况。方法选取2011年2月〜2015年3月我院肾内科收治原发性肾病综合征患者30例临床资料，依据治疗措施不同进行分组，对照组（环磷酰胺联合醋酸泼尼松治疗）15例和他克莫司组（他克莫司联合醋酸泼尼松治疗）15例。比较两组原发性肾病综合征患者治疗前和治疗6个月后血清白蛋白、肌酐、胆固醇、三酰甘油、尿蛋白定量情况以及两组患者临床疗效情况。结果两组原发性肾病综合征患者治疗前血清白蛋白、肌酐、胆固醇、三酰甘油、尿蛋白定量比?A，差异无统计学意义（P>0.05）,对照组和他克莫司组治疗6个月后血清白蛋白均高于治疗前，肌酐、胆固醇、三酰甘油、尿蛋

2、白定量均低于治疗前，他克莫司组治疗6个月后血清白蛋白均高于对照组，肌酐、胆固醇、三酰甘油、尿蛋白定量均低于对照组，他克莫司组原发性肾病综合征患者治疗缓解率高于对照组，差异有统计学意义（x2=7.65，P［关键词］他克莫司；原发性肾病综合征；白蛋白；肌酐；尿蛋白定量［中图分类号］R692［文献标识码］A［文章编号］1674-4721(2016)12(b)-0129-03TheclinicalanalyzingoftreatmentprimarynephroticsyndromebytacrolimusWEIJian-boNINGFang-fangLUQin-yanDepartmentofN

3、ephrology，theSixthAffiliatedHospitalofGuangzhouMedicalUniversity,Qingyuan511518，China[Abstract]ObjectiveToexploretheclinicaleffectsoftreatmentprimarynephroticsyndromebytacrolimus.Methods30casesclinicaldataofprimarynephroticsyndromepatientsinourhospitaldepartmentofnephrologyfromFebruary2011toMarch

4、2015wereselected，anddividedintotwogroupsbydifferenttreatmentmethods,thecontrolgroup(cytoxancomparedwithprednisoneacetatetreatment)15casesandtheTacrolimusgroup(prednisoneacetatecomparedwithtacrolimustreatment)15cases.Theserumalbumin,creatinine，cholesterol，triglyceride，urineproteinquantitationoftwo

5、groupsprimarynephroticsyndromepatientsbeforetreatmentandaftertreatment6mothswerecompared，clinicalcurativeeffectoftwogroupsprimarynephroticsyndromepatientswerecompared.ResultsTheserumalbumin，creatinine,cholesterol，triglyceride,urineproteinquantitationoftwogroupsprimarynephroticsyndromepatientsbefo

6、retreatmentwerenosignificantdifference（P〉0.05），theserumalbuminofcontrolgroupandTacrolimusgroupaftertreatment6mothswerehigherthanbeforetreatment；thecreatinine，cholesterol，triglyceride,urineproteinquantitationwerelowerthanbeforetreatment；theserumalbuminofTacrolimusgroupaftertreatment6mothswashigher

7、thanthatofcontrolgroup；thecreatinine,cholesterol,triglyceride,urineproteinquantitationwerelowerthanthatofcontrolgroup；theremissionrateoftreatmentgroupwashigherthanthatofcontrolgroup，thedifferencesweresignificant（x2=7.6