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1、视神经损伤的临床治疗与疗效分析周一鸣颜美荣彭晓(解放军第一六三医院眼科湖南长沙410003)【摘要】目的:分析外伤性视祌经损伤临床药物治疗方法并对比观察治疗效果。方法:以我院2009年7月-2013年7月因外伤所致视神经损伤的58例患者为研究对象,采用回顾性分析方法,甲泼尼龙组34例主要给予甲基强的松龙治疗,地塞米松组24例主要给予地塞米松治疗,此外均给予脱水剂,血管扩张剂,神经营养类药物辅佐治疗。结果:治疗前两组患者在年龄、性别及视神经损伤程度上没有统计学意义(X2=4.327,P=0.115)。治疗后甲泼尼龙组与地塞米松组之间存在统计学差异(X2=8.628,
2、P=0.035),甲泼尼龙组与地塞米松组有效率分别为47.06%、20.83%。在治疗时间上,甲泼尼龙组与地塞米松组8h内给予与8h后给药存在统计学差异。结论:外伤性视神经损伤患者甲泼尼龙治疗与地塞米松治疗疗效存在差异,但差异不显著。且糖皮质激素治疗对治疗时间,治疗疗程以及患者细胞膜类固醇受体饱和程度有关,因此治疗应根据患者实际情况灵活选择。【关键词】外伤性视神经损伤;地塞米松;甲基强的松龙;临床治疗;疗效分析【中图分类号1R774.6【文献标识码】B【文章编号】1003-5028(2015)6-0515-01AnalysisofClinicalTreatment
3、andCurativeEffectof58CaseswithOpticNerveInjuryZHOUYiming【Abstract】Objective:toanalysistheclinicaldrugtreatmentforinjuryandobservethetherapeuticeffectofcontrastfortraumaticopticnerve.Methods:inourhospitalfrom2009July-2013yearinJulybecauseofinjuryofopticnerveinjuryin58patientsastheresea
4、rchobject,usingretrospectiveanalysismethod,thetreatmentofmethylprednisolonemethylprednisolonegroup34casesmainlygivenmethylprednisolone,dexamethasonegroup24casesmainlygivendexamethasonetreatment,inadditionaregivingdehydrant,vasodilators,nervenutritionclassadjuvanttherapydrugs.Results:b
5、eforetreatment,thetwogroupsinage,genderandopticnerveinjurydegreewasnotstatisticallysignificant(X2=4.327,P=0.115).Therearesignificantdifferencesbetweenthetreatmentofmethylprednisolonegroupandthedexamethasonegroup(X2=8.628,P=0.035),methylprednisolonegroupanddexamethasonegroupeffectivera
6、tewere47.06%,20.83%.Atthetimeoftreatment,givingand8hafteradministrationandtherearesignificantdifferencesbetweenmethylprednisolonegroupanddexamethasonegroup8h.Conclusion:traumaticopticnerveinjuryinpatientstreatedwithdexamethasoneandmethylprednisolonetreatmentdifferences,butthedifferenc
7、ewasnotsignificant.Andglucocorticoidtherapyonthetreatmenttime,treatmentandpatientcellmembranesteroidreceptorsonthedegreeofsaturation,sothetreatmentshouldbechosenflexiblyaccordingtotheactualsituationofpatients.【Keywords】traumaticopticnerveinjury;dexamethasone;methylprednisolone;clinica
8、ltrea