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时间:2018-10-25
《尿ngal与妊高症肾损伤的相关分析》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、尿NGAL与妊高症肾损伤的相关分析[摘要]目的探?尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)水平与妊娠期高血压肾损伤疾病病情进展的关系。方法选择我院2014年9月〜2016年4月间住院治疗并分娩的妊娠期高血压患者60例为观察组(妊娠期高血压患者27例,轻度子痫前期患者15例,重度子痫前期患者6例,子痫期患者12例);选择60例妊娠期健康孕妇为对照组。分别检测患者入院24h内和产后72h的尿NGAL、血肌酎(Cr)及血清胱抑素C(Cys-C)水平,分析其与妊娠期高血压肾损伤疾病的严重程度及临床表现的关系。结果入院24h各组尿NGAL、血
2、Cr含量均高于产后72h,Cys-C水平低于产后72h,差异具有统计学意义(P<0.05);除妊娠期高血压组和轻度子痫前期组,各亚组间尿NGAL、血Cr含量差异均有统计学意义(P〈0.05);Cys-C含量妊娠期高血压组、轻度子痫前期组以及子痫期组之间差异均存统计学意义(P〈0.05);尿NGAL与妊娠期高血压肾损伤的严重程度呈正相关。结论检测尿NGAL水平可以早发现、早诊断、早治疗妊娠期高血压肾损害,对于临床决策、母婴健康及治疗子痫相关并发症的发生有重要意义。本文采集自网络,本站发布的论文均是优质论文,供学习和研究使用,文中立场与本网站
3、无关,版权和著作权归原作者所右,如存不愿意被转载的情况,请通知我们删除己转载的信息,如果需要分享,请保留本段说明。[关键词]中性粒细胞明胶酶相关脂质运载蛋白;妊娠;高血压•,肾损伤[中图分类号]R692;R714.2[文献标识码]A[文章编号]2095-0616(2017)07-119-04CorrelationanalysisofurinaryNGALandrenalinjuryinpatientswithpregnancyinducedhypertensionHUANGGuanglianPURongWANGBoqinClinicalL
4、aboratory,DongguanThirdPeople’sHospital,Dongguan523326,China[Abstract]ObjectiveToexploretherelationshipofurinaryneutrophilgelatinaseassociatedlipidcarrierprotein(NGAL)levelandpregnancyinducedhypertensionrenalinjurydiseaseprogression.Methods60casesofpregnancyinducedhyperte
5、nsionhospitalizedanddeliveriedinourhospitalfromSeptember2014toApril2016wereselectedastheobservationgroup(including27casesofpregnancyinducedhypertension,15casesofmildpreeclampsia,6casesofseverepreeclampsia,and12casesofeclampsia).60healthypregnantwomenwereselectedascontrolg
6、roup.ThelevelsofurinaryNGAL,serumcreatinine(Cr)andserumcystatinC(Cys-C)inthepatientswith24hand72hafteradmissionweredetermined.TherelationshipbetweenthelevelsofurinaryNGAL,serumcreatinine(Cr),serumcystatinC(Cys-C)andseverityofhypertensivedisordersinpregnancy,clinicalmanife
7、station.ResultsTheurineNGALandbloodCrlevelsinthe24hwerehigherthanthoseinthepostpartum72h.TheCys—Clevelinthe24hwaslowerthanthatofpostpartum72h.Andthedifferenceswerestatisticallysignificant(P<0.05).ThereweresignificantdifferencesinNGALandCrlevelsinurinebetweenthesubgroup,ex
8、cepthypertensivegroupandmildpreeclampsiagroup(P<0.05).TherewasasignificantdifferenceinCys—Cconte
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