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1、氯丙咪嗪与利多卡因乳膏联合使用治疗早泄龚志勇唐铁龙鲜述彦邓显忠崔曙(四川省南充市川北医学院附属医院四川南充637000)【摘要】目的观察氯丙咪嗪与利多卡因乳膏联合使用治疗早泄的临床效果。方法将符合纳入标准的106例早泄病人随机分为试验组和对照组，每组53例。所有病人进入为期4周的基线水平观察期，记录治疗前的阴道内射精潜伏时间(IELT)和性交满意度评分。试验组给予氯丙咪嗪25mgbid,每次性交时局部涂抹利多卡因乳膏；对照组只给予氯丙咪嗪25mgbid。治疗6周后记录每个病人的IELT值和性交满意度评分。结果治疗后试验组平均IELT与对照组比较明显延长(6.86&plus
2、mn;1.95minvs.4.75±1.08min,P<0.001),性交满意度评分与对照组比较无显著性差异(8.29±1.21vs.7.93±1.14,P>0.10)。结论氯丙咪嗪与利多卡因乳膏联合使用比单用氯丙咪嗪在延长IELT方面效果更为显著，而在提高性交满意度方面无显著性差异。【关键词】氯丙咪嗪利多卡因乳膏早泄【中图分类号】R453【文献标识码】A【文章编号】2095-1752(2013)23-0088-02Treatprematureejaculationwiththecombinationofclomipr
3、amineandlidocainecreamGONGZhi-yong,TANGTie-long,XianShu-yan,DENGXian-zhong,CuiShu(DepartmentofUrology,AffiliatedHospitalofNorth-SichuanMedicalCollege,Nanchong,Sichuan,China637000)【Abstract】Object:Toobservethetherapeuticefficacyofthecombinationofclomipramineandlidocainecreaminthetreatmento
4、fprematureejaculation(PE).Methods:OnehundredandsixpatientswithPEcorrespondingwiththeinclusioncriteriaweredividedrandomlyintotestgroupandcontrolgroupincluding53casesrespectively.Allpatientsenteredabaselineperiodof4weeks,andtheintravaginalejaculatorylatencytime(IELT)andsexualsatisfactionsco
5、rebeforetreatmentwererecorded.Patientsinthetestgroupweregivenoralclomipramine25mgbidandtopicallidocainecreameverysexualintercourse,whilepatientsinthecontrolgroupweregivenoralclomipraminealone.Sixweeksafterthetreatment,allpatientswererequiredtorecordIELTandsexualsatisfactionscore.Results:A
6、ftertreatment,themeanIELToftestgroupwassignificantlyprolongedcomparedtothatofcontrolgroup(6.86±1.95minvs.4.75±1.08min,P<O.OOl),butthemeansexualsatisfactionscoreoftestgrouphadnodifferencefromthatofcontrolgroup(8.29±1.21vs.7.93±1.14,P>O.lO).Conclusion:Compa
7、redtooralclomipraminealone,thecombinationofclomipramineandlidocainecreamcouldsignificantlyprolongIELTbutcouldnotimprovethesexualsatisfactionofpatientswithPE.【Keywords】clomipraminelidocainecreamprematureejaculation早泄是男科门诊最常见的疾病，它不仅对病人而且对病人配偶的生活质量产生影响。早泄的治疗方法很多，0前得到认可
