先天性心脏病流行病学

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1、Congenitalheartmalformation:Prevalence,severity,survival,andqualityoflife先天性心脏病流行病学Thelowestvalues/1000livebirthsAuthor‰RegionFyler2.10NewEngland,USAGardiner2.17Toronto,CanadaAkman3.20Bogalusa,USAMacMahon3.20Birmingham,UKMckeown4.20Birmingham,UKBosi4.60ItalyBierman4.70HawaiiPrevalenceofconge

2、nitalheartmalformationatbirththehighestvalues/1000birthsauthor‰RegionFischer8.20Tyrol,AustriaKerrebijn8.26Leiden,NetherlandGrech8.80MaltaHoffmann8.82SanFrancisco,USAMeberg9.02NorwayNakazawa10.00JapanManetti12.30Florence,ItalyYerushalmi11.70California,USAPrevalenceofcongenitalheartmalformatio

3、natbirthTheoldestsurveys/1000livebirthsAuthorDatePrevalence(‰)Macmahon1940—493.23Carlgren1941–506.35Harris1944—505.90Pleydell1944—573.20Landtman1945–638.00Richards1946—535.50Gardiner1948—492.17Mustachi1949—515.88PrevalenceofcongenitalheartmalformationatbirthRecentdata/1000livebirthsAuthorDat

4、ePrevalence(‰)Grech1990-948.80Robida1984-9412.23Bosi1992-934.60Anderson1987-9010.20Cerboni1988-906.08Ferencz1981-894.23Pexieder1986-876.04Meberg1982-889.02PrevalenceofcongenitalheartmalformationatbirthPrevalenceofcongenitalheartmalformationatbirthRegionaldifferences/1000livebirthsRegionMeanR

5、angedifferenceplaceEurope6.673.20Birmingham,UK12.30Florence,ItalyUSA5.763.20Bogalusa8.56SanFranciscoCanada3.972.17Toronto5.54AlbertaOthercountries8.976.08GuadeloupeYearlyfluctuationinBohemiandatafrom1980through1989YearNo.ofmalformationPrevalence/10006467.045476.395686.7719835486.735666.97495

6、6.164365.534555.824025.113674.80PrevalenceofcongenitalheartmalformationatbirthTheprevalencewashighestinOctober,andlowestinDecember,JuneandJuly.Thepeakoftheprevalencecoincidedwiththeepidemicsofinfluenzainearlypregnancy8and9monthspreviously.TherewasadefiniteseasonalvariationRatioofboystogirlsB

7、oystogirlswithCHD:51.9%to48.1%Ahigherproportionofboyswasfoundwith:DORV(2.68:1);HLHS(2.25:1)cTGA(2.11:1);Ahigherproportionofgirlswasfoundwith:PDA(1:1.66);Ebstein’smalformation(1:1.57)Commonarterialtrunk(1:1.22)Distributionofcongenitalheartmalformati