7种常用辅料在复方中药制剂中阻湿性能的对比研究

《7种常用辅料在复方中药制剂中阻湿性能的对比研究》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、7种常用辅料在复方中药制剂中阻湿性能的对比研究慈利县中医医院湖南慈利427200【摘要】目的比较7种常用辅料在复方中药制剂中的阻湿性能。方法指标主要为吸湿率和其他特性参数，模型药物为复方中药制剂1、2,比较7种常用辅料阻湿性能。结果复方中药制剂1的平衡吸湿率及临界相对湿度分别为62.49%、38%,复方中药制剂2为16.41%、53%。复方中药制剂1中7种辅料的吸湿初速度排列为：羟丙甲纤维素〉甘露醇〉乙基纤维素〉乳糖〉微晶纤维素〉磷酸氢钙〉糊精；吸湿加速度：羟丙甲纤维素〉乳糖=甘露醇=乙基纤维素〉磷酸氢钙=微晶纤维素=糊精；平

2、衡时间：微晶纤维素〉磷酸氢钙〉甘露醇〉糊精〉乙基纤维素〉乳糖〉羟丙甲纤维素；平衡时吸湿率：羟丙甲纤维素〉甘露醇〉微晶纤维素〉乙基纤维素〉磷酸氢钙〉乳糖〉糊精。复方中药制剂2中7种辅料的吸湿初速度排列为：羟丙甲纤维素〉微晶纤维素〉乙基纤维素〉乳糖〉糊精〉磷酸氢钙〉甘露醇；吸湿加速度：微晶纤维素=羟丙甲纤维素〉乙基纤维素〉乳糖〉磷酸氢钙=甘露醇=糊精；平衡时间：羟丙甲纤维素〉乙基纤维素〉磷酸氢钙〉乳糖〉糊精〉微晶纤维素〉甘露醇；平衡时吸湿率：羟丙甲纤维素〉微晶纤维素〉乙基纤维素〉乳糖〉磷酸氢钙〉糊精〉甘露醇。结论以复方中药为主要原

3、料制备制剂时，根据辅料阻湿性能选择合适的阻湿剂。【关键词】常用辅料复方中药制剂阻湿性能【Abstract】objectivetocomparativesevenkindsofcommonlyusedmaterialsinwetresistanceperformanceofcompoundChinesemedicinepreparation.Methodsindicatorsmainlyformoistureabsorptionrateandotherparameters,themodeldrugforcompoundChine

4、semedicinepreparation1，2，comparingtheperformancesevenkindsofcommonlyusedmaterials.ResultscompoundChinesemedicinepreparation1balanceofmoistureabsorptionrateandcriticalrelativehumidityof62.49%,38%respectively，thecompoundChinesemedicinepreparation216.41%,53%.CompoundCh

5、inesemedicinepreparation1，7kindsofsupplementarymaterialmoistureabsorptionvelocityarearrangedasfollows：hydroxypropylmethylcellulose>mannitol>lactose>>ethylcellulosemicrocrystallinecellulose>calciumhydrogenphosphate>dextrin；Hygroscopicacceleration：hy

6、droxypropylmethylcelluloselactose>=mannitol=>ethylcellulosecalciumhydrogenphosphate==dextrinmicrocrystallinecellulose；Balancetime：microcrystallinecellulose>calciumhydrogenphosphate>mannitol>dextrin>lactose>>ethylcellulosehydroxypropylmethylce

7、llulose.Balancethemoistureabsorptionrate：hydroxypropylmethylcellulose>mannitol>>ethylcellulose,microcrystallinecellulose>calciumhydrogenphosphate>>lactosedextrin.CompoundChinesemedicinepreparation2of7kindsofsupplementarymaterialatthebeginningofmois

8、tureabsorptionspeedisarrangedasfollows：hydroxypropylmethylcellulose>>ethylcellulose,microcrystallinecellulose>>lactosedextrin&