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1、中国组织工程研究与临床康复第12卷第8期2008–02–19出版基础医学JournalofClinicalRehabilitativeTissueEngineeringResearchFebruary19,2008Vol.12,No.8三七总皂苷促进脑出血后侧脑室室管膜下神经干细胞的增殖和分化**☆司银楚，李巾伟，张丽娟，吴海霞，许红，朱培纯Panaxnotoginsengsaponinspromotetheproliferationanddifferentiationofneuralstemcellsinsubependymalzoneofthelateralventr
2、icleinratbrainafterintracerebralhemorrhageSiYin-chu,LiJin-wei,ZhangLi-juan,WuHai-xia,XuHong,ZhuPei-chunAbstractDepartmentofAIM:PanaxnotoginsengsaponinscanpromotetheexpressionofNestin,proliferatingcellnuclearantigenandbasicfibroblastAnatomy,Beijinggrowthfactorinsubependymalzoneoflateralven
3、tricleinratbrainaftercerebralhemorrhage,andacceleratetheproliferationandUniversityofdifferentiationofcortexneuralstemcellsoffetalrats.ThisarticleinvestigatestheinfluenceofpanaxnotoginsengsaponinsonChineseMedicine,proliferationanddifferentiationofsubependymalcellsoflateralventricleinratbra
4、inafterintracerebralhemorrhagebytheBeijing100029,Chinacollagenasemethodandimmunohistochemicalstaining.METHODS:ExperimentswereperformedattheLaboratoryofNeuro-anatomyofBeijingUniversityofChineseMedicinefromSiYin-chu,Doctor,2002to2006.①SixtycleanmaleWistarratsweighting220-250gwereprovidedbyA
5、nimalExperimentalCenterofChinaAssociateprofessor,AcademyofChineseMedicalSciences.Ratswererandomlyassignedintoanormalgroup,amodelgroupandanadministrationDepartmentofAnatomy,Beijinggroup,20ineachgroup.Animalinterventionmettheanimalethicalstandard.PanaxnotoginsenysaponinsXueshuantonginjectio
6、nUniversityofwasofferedbyInnerMongoliaKangyuanYaoyeCompany,No.22-5802(1999)1787,specification5mL:175mg.②RatmodelsofChineseMedicine,cerebralhemorrhagewereestablishedwithcollagenaseasainductor.Ratsintheadministrationgroupreceived35mgofpanaxBeijing100029,notoginsenysaponinsintraperitoneallya
7、fterthesurgery,onceaday.RatsinthemodelgroupreceivedsalineintraperitoneallyafterChinabjsiyinchu@sina.comthesurgery,onceaday.Ratsinthenormalgroupdidnotreceiveanyintervention.③Proliferatingcellnuclearantigen,β-Ⅲtubulinandglialfibrillaryacidicproteinexpressioninependyma
