三七总皂苷凝胶膏剂的研制

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1、贵阳中医学院硕士学位论文赋形性、初黏力等进行了考察和测试。结果表明，薄层鉴别分离度良好，专属性强。含膏量、赋形性和初黏力符合《中国药典》(2010年版一部)要求。采用HPLC法对三七总皂苷凝胶膏剂中的三七皂苷Rl、人参皂苷RgI、人参皂苷Rbl三种成分进行测定，结果显示三七总皂苷凝胶膏剂中三种成分的含量稳定，其含量分别为三七皂苷RI1．68mg·百1，人参皂苷Rgl14．6mg·百1，人参皂苷Rbl3．30rag·百1。6．三七总皂苷凝胶膏剂的稳定性研究：为了研究三七总皂苷凝胶膏剂的稳定性，进行了3个月的常温留样观察和加

2、速稳定性实验研究，结果表明三七总皂苷凝胶膏剂的感官评价、初黏力、含药量均稳定，说明三七总皂苷凝胶膏剂3个月稳定性良好。关键词：三七总皂苷；凝胶膏剂；体外渗透性；质量标准2贵阳中医学院硕士学位论文ResearchonPNSCataplasmAbstractInordertodevelopanewlytransdermaldeliverysystemandpromotthedevelopmentofChinesemedicine，IdidasystematicstudyofPNScataplasmpreparation,co

3、ntentdetermination,invitropermeation,safety,qualitystandardsandstability．Theresearchmainlyincludesthefollowingaspects：1．PreparationofPNScataplasm：Inordertoprepareanappropriateblankbase，adhesionandphysicalpropertiesaleusedasevaluationindexes，andtheamountsofbasemat

4、erialsareusedasinvestigationfactors．Throughthepreliminarytest,singlefactoretestandtheorthogonaltestmetho也theoptimalblankbaseprescriptiOilofPNScataplasmisNP一700---CMC-Na(4：1)59，Kaolin3．59，Dihydroxyalumimunaminoacetate0．189，Glycerol--Propanediol(2：1)259，PVP—K900．59

5、，PVPP0．59，PVA0．259．Withthisoptimalprescriptionbetterqualitycataplasmcanbeprepared．2．ContentdeterminationofPNScataplasm：TodeterminingthecontentofPNScataplasm，usingHPLCtodeterminethecontentsofnotoginsenosideRI，ginsenosideRgl，ginsenosidRbl．Resultsshowedthatthismetho

6、dissimpleandreliable．ThecomponentisnotoginsenosideRl1．68mg·g-1，ginsenosideRgl14．60mg·g-1，ginsenosidRbi3．30mg·g～．3．TheinvitropermeationofPNScataplasm：ThepermeationexperimentsweretostudytheinvitropermeationofPNScataplasm．Determiningthepermeationamountofnotoginsenos

7、ideRl，giusenosideRglandginsenosidRbiWasbyHPLC．TheoptimizingpermeationmediumWasnitrocellulosemembraneandpermeationenhancerWasAzone．The24haccumulativepermeationamountofPNScataplasmWas683．968I_tg·cm-2．TheiIlvitropermeationCallbedescribedbymodelofHiguchiequation，andp

8、ermeationrateWas17．803p,g·cm-2．min～．4．MedicationSafetyStudyofPNScataplasm：3贵阳中医学院硕士学位论文Inordertoensurethesafetyofdruguse，thisstudywastosurveyacutedermalirritat