脂蛋白临床PPT课件.ppt

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1、LIPID:ReductioninNonfatalMIandCHDDeathRiskStratifiedbyDiabeticStatus-19-25302520151050WithdiabetesWithoutdiabetes(n=782)(n=8,232)LIPIDStudyGroup.NEnglJMed.1998;339:1349-1357.%TM©1999ProfessionalPostgraduateServices®TM©1999ProfessionalPostgraduateServices®0123CHDmortality(per1,000)FontbonneAMetal.Di

2、abetesCare.1991;14:461-469.2930-5051-7273-114115Quintiles(pmol)offastingplasmainsulinP<0.01CHDMortalityandHyperinsulinemia:ParisProspectiveStudy(n=943)TM©1999ProfessionalPostgraduateServices®010203040506012345%MacrovasculardiseaseP<0.0010102030405060708012345%MacrovasculardiseaseP<0.0501020304050

3、6012345%CHDP<0.0020102030405060708012345%CHDNondiabeticcontrols(n=178)Noninsulin-treatedtype2diabetics(n=154)FastingC-peptidequintiles(1-5)JankaHU.HormMetabRes.1985;15(suppl):15-19.PrevalenceofMacrovascularDiseaseandCHDAccordingtoQuintilesofFastingC-PeptideFinnishDiabetesPreventionStudy:Treatingt

4、heIGT*PatientWithLifestyleChangesStudyDesign522middle-aged,overweight†subjects172men,350womenwithIGTBMI31kg/m2meanage:55yearsmeanduration:3.2yearsinterventiongroup:individualizedcounselingreducingweight,totalintakeoffatandsaturatedfatincreasingintakeoffiber,physicalactivity*Plasmaglucoseconcentratio

5、nof140to200mg/dL.†BMI25kg/m2.IGT=impairedglucosetolerance;BMI=bodymassindex.TuomilehtoJetal.NEnglJMed.2001;344:1343-1350.®©2002ThomsonProfessionalPostgraduateServices®www.lipidhealth.orgFinnishDiabetesPreventionStudy:SuccessinAchievingTreatmentGoalsat1Year*Pvaluesweredeterminedforthedifferencebetw

6、eengroups.TuomilehtoJetal.NEnglJMed.2001;344:1343-1350.0.0017186Exercise>4hr/wk0.0011225Fiberintake³15g/1,000kcal0.0011126Saturated-fatintake<10%energy0.0012647Fatintake<30%energy0.0011343Wtreduction>5%%ofsubjectsPvalue*ControlsInterventionGoals®©2002ThomsonProfessionalPostgraduateServices®www.lip

7、idhealth.orgFinnishDiabetesPreventionStudy:ReductioninRiskforDiabetes*TuomilehtoJetal.NEnglJMed.2001;344:1343-1350.11%23%0510152025InterventionControl(n=265)(n=257)*P<0.001;4-yearresultsDiabetes(%)®©2