糖尿病脂代谢紊乱PPT课件.ppt

《糖尿病脂代谢紊乱PPT课件.ppt》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、ATPIII:ManagementofDiabeticDyslipidemiaPrimarytargetoftherapy:identificationofLDL-C;goalforpersonswithdiabetes:<100mg/dLTherapeuticoptions:LDL-C100–129mg/dL:increaseintensityofTLC;adddrugtomodifyatherogenicdyslipidemia(fibrateornicotinicacid);intensifyriskfactor

2、controlLDL-C130mg/dL:simultaneouslyinitiateTLCandLDL-C–loweringdrugsTG200mg/dL:non–HDL-C*becomessecondarytargetExpertPanelonDetection,Evaluation,andTreatmentofHighBloodCholesterolinAdults.JAMA.2001;285:2486-2497.Note:Diabeticdyslipidemiaisessentiallyatherogeni

3、cdyslipidemiainpersonswithtype2diabetes.*Non–HDL-Cgoalissetat30mg/dLhigherthanLDL-Cgoal.TM©2001,ProfessionalPostgraduateServices®www.lipidhealth.orgLIPID:ReductioninNonfatalMIandCHDDeathRiskStratifiedbyDiabeticStatus-19-25302520151050WithdiabetesWithoutdiabetes(

4、n=782)(n=8,232)LIPIDStudyGroup.NEnglJMed.1998;339:1349-1357.%TM©1999ProfessionalPostgraduateServices®TM©1999ProfessionalPostgraduateServices®BaselineAggressiveRxModerateRxPCharacteristic(N=1360)(N=1318)ValueCampeauetal.Circulation.1999;99:3241-3247.Post-CABG:Aggre

5、ssiveLDL-CLoweringDelaysProgressionofAtherosclerosisinWomen,Elderly,andPatientsWithSelectedCHDRiskFactorsn%n%Age(y):<6047930513400.003³608812780539<0.0001Female881563240.25Male127229125540<0.0001Currentsmoker:Yes13732139500.01No122327117938<0.0001Hypertension:Ye

6、s65527608390.0002No70528710390.0003Diabetesmellitus:Yes12227104430.04No123828121439<0.0001n=numberofgrafts.GraftsWithSubstantialProgressionTM©1999ProfessionalPostgraduateServices®0246MeanannualCHDmortalityrate/1,000AdaptedfromFontbonneAetal.Diabetologia.1989;32:30

7、0-304.Cholesterol(mg/dL)220>220220>220TG123mg/dLTG123mg/dLFastingTGandRiskforCHDDeath:ParisProspectiveStudyTM©1999ProfessionalPostgraduateServices®0123CHDmortality(per1,000)FontbonneAMetal.DiabetesCare.1991;14:461-469.2930-5051-7273-114115Quintiles(pmol)offa

8、stingplasmainsulinP<0.01CHDMortalityandHyperinsulinemia:ParisProspectiveStudy(n=943)TM©1999ProfessionalPostgraduateServices®010203040506012345%Macrovas