Tc99在心血管影像中的应用PPT课件.ppt

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1、Tc99UsedInCardiacHeartImagingOutlineBackgroundofNuclearCardiologyElementsUsedinHeartImagingImagingTechniquesHeartImagesBackgroundofNuclearCardiologyNuclearcardiologyimagingprocedureshavevastlydevelopedoverthepast25yearswithadvantagesandtreatmentsofheartdisease.My

2、ocardialperfusionimaging(MPI)offersahighdegreeofaccuracyinthedetection,diagnosis,andprognosisofcoronaryarterydisease.MPIisthemostcommonprocedureindeterminingheartdisease.InstrumentationofNuclearImagingUsesradiopharmaceuticalsthatlocalizetoatargetorgan.Inthecaseof

3、cardiology,imagingagentsareusedthatwillflowtoandaccumulateinthemyocardiumoftheheart.Nuclearheartimagingisperformedwithanuclearcamera.TheheartimagingprocessisreferredtoasSinglePhotonEmissionComputerizedTomography(SPECT).Tc99isthemostcommonradionuclideusedtodayinca

4、rdiacimaging.NuclearCardiologyCameraTheThalliusIon(201Tl)Thefirstuseofradiopharmaceuticalsincardiacheartimagingbeganin1975inwhichthethalliusionwasused.ProblemswithThalliumLimitedSensitivity/Accuracy80%ShorthalflifeDoesnotstayboundtotissueImagesmustbetakenquicklyd

5、uetoredistribution.Difficulttoconcentratetargetorgan.Technetium75%ofproceduresusestechnetium99indiagnosingcardiacdiseases.Half-lifeof6hours140KeVgammarayemissionHighenoughinenergytopenetratethebody’stissues,butlowenoughnottoharmthebody.Twotypesoftechnetiumtobedis

6、cussed1)Tc99TBI2)Tc99SestamibiTechnetium99TBI1stTechniciumcompoundintroducedtonuclearcardiacimagingStructuralNameHexakis-(t-butylisonitrile)-Technetium(I)SixCoordinateIsonitrileOctahedralgeometry+1oxidationstateStructureofTc99TBIProblemswithTc99TBIHighactivityino

7、therpartsofthebody.RedistributionTc99Sestamibi(MIBI)DerivedfromTc99TBIComposedoffunctionalgroupsthatgiveclearancefromnon-targetorgansSixcoordinateOctahedralgeometryGreaterhydrophilicitythanTcTBIduetoitsmethoxygroups.LypophillicStructureofTc99SestamibiTc99MIBITech

8、niqueOneDayStressProtocolTwoDayStressProtocolDualIsotopeScanningGatingLVEF(LeftVentricleEjectionFraction)OneDayStressProtocolOnedayConsistsofarestexamfollowedb