阿司匹林在心血管临床中的应用PPT课件.ppt

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1、AspirinResistance:Significance,DetectionandClinicalManagementofThisRealPhenomenonWebcastMay10th,2004SponsoredbyEducationalObjectivesDefineAspirinResistance,IncidenceandPrevalenceinthePopulationDescribetheMechanismsforAspirinResistanceandReducedPlateletInhibitionUnderstandtheI

2、mportanceofAspirinResistanceTesting,MethodsofDetectionUnderstandClinicalImplicationandClinicalDecisionsinAspirinResistantPatientsFacultyStevenSteinhubl,M.D.DirectorofCardiovascularResearchandEducationAssociateProfessorofMedicineUniversityofKentucky,Lexington,KentuckyDanielI.S

3、imon,M.D.AssociateProfessorofMedicineHarvardMedicalSchoolAssociateDirector,InterventionalCardiologyBrighamandWomen’sHospital,Boston,MassachusettsChristopherCannon,M.D.AssociateProfessorOfMedicine,HarvardMedicalSchoolSeniorInvestigator,TIMIStudyGroupAssociatePhysician,Brighama

4、ndWomen’sHospitalBoston,MassachusettsAspirininCardiovascularDiseaseChristopherCannon,M.D.BrighamandWomen’sHospitalBoston,MAVascularDiseaseintheU.S.AmericanHeartAssociation.2004HeartDiseaseandStrokeStatistics.Brownetal.Amer.StrokeAssoc.25thInt.StrokeConference.2000.NationalSt

5、rokeAssociationPressRelease.April25,2000.HirschATetal.JAMA.2001;286:11:1317-1324.TIA=transientischemicattack.ACS=acutecoronarysyndrome.PAD=peripheralarterialdisease.AnnualIncidence(Millions)Prevalence(Millions)Stroke0.7014.71TIA0.5024.93ACS1.71*14.21†PAD8–124051015202530

6、197019801990200020102020203020402050NumberofPatients(Millions)ACC/AHAGuidelines2001,NHLBIChartbook2000andFootetal(JACC2000)12.424.6U.S.HeartDiseaseDoublesintheNextHalfCenturyEstimatedDirectandIndirectCostsofCardiovascularDiseasesandStroke$214$111.8$49.4$47.2$23.2$329.20$50$1

7、00$150$200$250$300$350HeartdiseaseCoronaryHeartdiseaseStrokeHypertensivediseaseCongestiveheartfailureTotalCVD3Billions212002estimates(USA)2AmericanHeartAssociation.2002HeartandStrokeStatisticalUpdate.20013CVD=cardiovasculardiseaseAspirinUsageIntheUSPercentageofUse37.623.313.8

8、12.214.1010%20%30%40%HeartDiseaseArthritisHeadacheBodyAcheOther26,00