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1、1,326patientswithsingledenovolesionsLesions10-28mminlength,2.5-3.75mmindiameter;Doubleblind,randomizedtrialBareStentn=652Endpoints(2yearfollow-up):TAXUSII–MACE(97%two-yearclinicalfollow-up)–Lateloss(<40%two-yearangiographicfollow-up)TAXUSIV–MACE–angiographicresultsnotpresented
2、TAXUSIIandIV:two-yearfollow-upPaclitaxel-elutingstentSlow-releaseformulationn=662536patientswithsingledenovolesionsLesions<12mminlength,3.0-3.5mmindiameter;Doubleblind,randomizedtrialPaclitaxel-elutingstentSlow-releaseformulationn=131Moderate-releaseformulationn=135BareStentn=
3、270(combinedcontrol)TAXUSIVTrialTAXUSIITrialPresentedatTCT2004TAXUSII:Latelossat6mo.andtwoyrs.mmTCT2004p=<0.0001p=NSp=NSTwo-yearangiographicresultswereavailablefor<40%oftheoriginalTAXUScohorts,butthoseavailableshowedlittlechangeinlate-lossbetweensixmonthsandtwoyears.TAXUSII:MA
4、CEattwoyears%TCT2004p=0.0047p=0.0622p=0.0006p=0.0126p=0.0178p=0.0178Targetlesionrevascularization(TLR)andtargetvesselrevascularization(TVR)remainedsignificantlylowerintheTAXUSgroups,resultinginloweroverallMACE.TAXUSII:MACEattwoyears(contin.)%TCT2004p=NSp=NSp=NSp=NSDespitereduc
5、edTLRandTVRintheTAXUSgroups,CABG,MI,anddeathrateswerenotstatisticallydifferentbetweentheTAXUSandcontrolgroups.TAXUSIV:MACEattwoyears%TCT2004p=<0.0001p=<0.0001p=<0.0001TAXUSIVshowedsimilartwo-yearresults:TVR,TLR,andoverallMACEremainedsignificantlylowerintheTAXUSgroup.TAXUSIV:MA
6、CEattwoyears(contin.)%TCT2004p=NSp=NSAgain,despitereducedoverallMACE,ratesofdeathandMIwerenotsignificantlydifferentbetweenthetwogroups.TAXUSIIandIV:two-yearfollow-upAmongpatientswithsingledenovocoronarylesions,treatmentwithapaclitaxel-elutingstentcontinuedtobeassociatedwithare
7、ductioninTLRandTVRat2yearscomparedwithbarestentConsistentwiththe6monthand1yeardata,TAXUSstentswerenotassociatedwithareductionintheclinicalendpointsofdeathorMIat2years.Theon-goingREALITYtrialisahead-to-headtrialcomparingpaclitaxel-elutingstentstosirolimus-elutingstents,whichhav
8、ealsobeenassociatedwithsignificantreductioninTVR(SIRIUStrial)
