SYNERGY PCI研究PPT课件.ppt

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1、Unfractionatedheparin60U/kgbolus,then12U/kgperhouradjustedtoanactivatedpartialthromboplastintimeof50to70secondsPrimaryEndpoint:Death/MIat30daysSYNERGYPCIASubsetanalysisoftheSYNERGYtrial4,687high-riskACSpatientsundergoingPCIafterrandomizationtounfractionatedheparinorenoxaparinEno

2、xaparin1mg/kgscevery12hoursplusadditional0.3mg/kgIVattimeofPCIifprocedurewasmorethan8hrsafterlastscdoseSYNERGYPCIDeath/MIbyintent-to-treatanalysisat30days%DeathMIDeathorMIP=NSP=NSP=NSSYNERGYPCIBleedingintheintent-to-treatanalysisat30days%GUSTOsevereTIMImajorTIMIminorP<0.05SYNERG

3、YPCIAmonghigh-riskACSpatientsundergoingPCI,therateofdeath/MIat30dayswasnotsignificantlydifferentbetweenpatientstreatedwithenoxaparinorunfractionatedheparin.PrimaryendpointdataforPCIpatientsisconsistentwithprimarySYNERGYtrialAsinprimarySYNERGYtrial,enoxaparinwasassociatedwithanin

4、creaseinTIMImajorbleeding