STRATUS-US研究PPT课件.ppt

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1、SmokingCessationinSmokersMotivatedtoQuitPresentedatAmericanCollegeofCardiologyScientificSessions2004PresentedbyDr.RobertAnthenelliSTRATUS-USTrialRimonabantAselectivecannabinoidtype1receptorantagonist5mgn=262Endpoints(1year):SmokingabstinenceChangeinbodyweightinpatientswhostoppedsmokingSTRATUS

2、-USTrialPresentedatACCScientificSessions2004787patientswhosmoked≥10cigarettes/dayforatleast2monthsandweremotivatedtostopsmokingRandomized,double-blind,multicenterPlacebon=261RimonabantAselectivecannabinoidtype1receptorantagonist20mgn=261Treatmentfor1YearSTRATUS-USTrialSmokingabstinenceat7-10we

3、eksp<0.001forhigh-dosevsplacebop=NSforlow-dosevsplaceboPresentedatACCScientificSessions2004Smokingabstinenceatendofstudyp<0.001forhigh-dosevsplacebop=NSforlow-dosevsplaceboSTRATUS-USTrialChangeinweightfrombaselineamongpatientswithaprolongedabstinencefromsmokingp<0.001forrimonabant20mgvsplacebo

4、Amongpatientswithaprolongedabstinencefromsmoking,changeinweightfrombaselinewassignificantlyinhigh-dosegroupcomparedwithplacebo(Figure)Insubgroupofpatientswhowereoverweightinitially,BMIwassignificantlyinhigh-dosegroupversusplacebo(-0.1vs.1.7,p<0.001)PresentedatACCScientificSessions2004kgSTRAT

5、US-USTrialAmongpatientssmoking≥10cigarettesperdayandmotivatedtostopsmoking,useoftheselectivecannabinoidtype1receptorantagonistrimonabantina20mgdosewasassociatedwithanincreaseinprolongedsmokingabstinencecomparedwithplacebo,buttherewasnodifferencebetweenthe5mgdoseofrimonabantandplaceboAdditional

6、ly,weightgain,whichcanbeanegativesideeffectofsmokingcessation,waslowerinpatientswhoreceivedrimonabant20mg,withbenefitseeneveninobesepatientsFurtherevaluationwarranted