LIFE研究PPT课件.ppt

《LIFE研究PPT课件.ppt》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、TheLIFETrialLosartanInterventionForEndpointreductioninhypertensionstudy(LIFE)PresentedattheAmericanCollegeofCardiology51stAnnualScientificSessionAtlanta,GADrBjörnDahlöffortheLIFEInvestigatorsLIFE:MajorclinicalendpointsinpatientswithISHEndpointLosartan(n=660)Atenolol(n=666)AdjustedRR(95%CI

2、)pCVdeath/stroke/MI11.4%15.6%0.75(0.56-1.01)0.06CVdeath4.1%7.8%0.54(0.34-0.87)0.01Stroke4.8%8.4%0.60(0.38-0.92)0.02MI4.7%5.4%0.89(0.55-1.44)0.64Totalmortality10.0%14.0%0.72(0.53-1.00)0.046New-onsetdiabetes5.8%9.0%0.62(0.40-0.97)0.04RR=riskratioKjeldsenSEetal.JAMA2002;288:1491-98.LIFE:Majo

3、rclinicalendpointsinpatientswithoutISHEndpointLosartan(n=660)Atenolol(n=666)AdjustedRR(95%CI)pCVdeath/stroke/MI11.0%12.3%0.90(0.79-1.02)0.11CVdeath4.5%4.6%0.99(0.80-1.22)0.90Stroke5.1%6.5%0.79(0.66-0.95)0.01MI4.2%3.9%1.12(0.90-1.40)0.30Totalmortality8.0%8.6%0.95(0.82-1.11)0.51New-onsetdia

4、betes6.1%7.9%0.77(0.64-0.92)0.005RR=riskratioKjeldsenSEetal.JAMA2002;288:1491-98.Patientswithhypertension(bloodpressure160-200/95-115mmHg)andleftventricularhypertrophyAtenololBeta-blockerDosetitratedtoBP<140/90mmHg(n=4,588)LosartanAngiotensinIIantagonistDosetitratedtoBP<140/90mmHg(n=4,605

5、)Followedfor>4years-Meanfollow-up4.8yearsCardiovasculardeath,MI,strokeLIFE:StudyDesignLosartanAtenololP=0.021CompositeofCVDeath/MI/StrokeLIFE:PrimaryCompositeEndpointAdjustedHazardRatio=0.87Rate23.8/1,000patientyrsRate27.9/1,000patientyrsn=508n=588P=0.206P=0.491CardiovascularDeathMyocardi

6、alInfarctionP=0.001StrokeLIFE:IndividualEndpointResultsAdjustedHR0.89AdjustedHR1.07AdjustedHR0.75LosartanAtenololLosartanAtenololLosartanAtenololLosartanAtenololP=0.001LIFE:New-onsetdiabetesAdjustedHazardRatio=0.75Rate13.0/1,000patientyrsRate17.4/1,000patientyrsn=241n=319