SCD-HeFT研究PPT课件.ppt

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1、SuddenCardiacDeathinHeartFailureTrialPresentedatAmericanCollegeofCardiologyScientificSessions2004PresentedbyDr.GustH.BardySCD-HeFTEndpoints(median45.5months):All-causemortalitySCD-HeFTPresentedatACCScientificSessions20042,521patientswithmoderatelysymp

2、tomaticCHF(NYHAClassIIorIII)andLVEF≤35%Randomized,double-blind,multicenterConventionalCHFTreatment+PlaceboConventionalCHFTreatment+ICDSingleleadimplantablecardioverterdefibrillatorprogrammedforventricularfibrillation(VF)treatmentonlyTreatmentConvention

3、alCHFTreatment+AmiodaroneAntiarrhythmicagent800mgWeek1,400mgWeek2-4Chronictherapy:200mg/dayif<150lbs300mg/dayif150-200lbs400mg/dayif>200lbsAll-causemortalityat5yearsAmiodaronevsplaceboHR1.06,p=0.529ICDvsplaceboHR0.77,p=0.007Medicationuseatendoffollow-u

4、pincluded72%ACE-inhibitors,78%beta-blockers,80%loopdiuretics,and55%ASAPriordurationofCHFwas24.5monthsatbaselineNodifferenceinall-causemortalitybetweenamiodaroneandplaceboarmMortalitywaslowerinICDarmvsplaceboPresentedatACCScientificSessions2004%Mortalit

5、ySCD-HeFTAmongpatientswithNYHAClassIIorClassIIICHFandreducedleftventricularejectionfraction,treatmentwithanimplantableICDwasassociatedwithareductioninall-causemortalitycomparedwithplacebo,buttherewasnodifferencebetweenamiodaroneandplaceboSecondaryendpo

6、intdatanotyetreportedSCD-HeFT