正文描述:《MERIT-HF研究PPT课件.ppt》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、MERIT-HF:MetoprololCR/XLRandomizedInterventionTrialincongestiveHeartFailurePurposeTodeterminewhethermetoprololcontrolled/extendedrelease(CR/XL)oncedaily,inadditiontostandardtherapy,canlowermortalityinpatientswithdecreasedejectionfractionandsymptomsofheart
2、failureReferenceMERIT-HFStudyGroup.EffectofmetoprololCR/XLinchronicheartfailure:MetoprololCR/XLRandomisedInterventionTrialinCongestiveHeartFailure(MERIT-HF).Lancet1999;353:2001–7.MERIT-HF:MetoprololCR/XLRandomizedInterventionTrialincongestiveHeartFailure-
3、TRIALDESIGN-DesignRandomized,double-blind,placebo-controlledPatients3991patientswithleftventricularejectionfraction<0.40andNYHAclassII-IVheartfailure,stabilizedbyoptimumstandardtherapy(anycombinationofdiuretics+ACEinhibitor)FollowupandprimaryendpointAim2.
4、4yearsfollowup.Primaryendpointall-causemortalityTreatmentPatientsassignedmetoprololreceived12.5(NYHAIII-IV)or25mg(NYHAII)oncedaily,increasingover8weekstomaximumtargetdose200mgoncedailyMERIT-HF:MetoprololCR/XLRandomizedInterventionTrialincongestiveHeartFai
5、lure-RESULTS-Studyhaltedatmeanfollowupof1yearonrecommendationofindependentsafetycommitteebecausepredefinedcriteriametandexceeded:All-causemortalitysignificantlylowerinmetoprololCR/XLgroup(145vs.217,34%riskreduction,P=0.0062)Significantlyfewercardiovascula
6、rdeaths(128vs.203),suddendeaths(79vs.132)anddeathfromworseningheartfailure(30vs.58)Drugwelltolerated,asdefinedbypermanentearlydiscontinuationoftreatment(13.9%ofmetoprololCR/XLgroupversus15.3%placebo)MERIT-HF:MetoprololCR/XLRandomizedInterventionTrialincon
7、gestiveHeartFailure-RESULTScontinued-MERIT-HFStudyGroup.Lancet1999;353:2001–7.NopatientslosttofollowupMERIT-HFtrialprofile3991patientsrandomized2001patientsplacebo217patientdeaths1784patientsalive1539patientsontreatment145patientdeaths1990patientsmetoprol
8、olCR/XL1845patientsalive1614patientsontreatmentMERIT-HF:MetoprololCR/XLRandomizedInterventionTrialincongestiveHeartFailure-RESULTScontinued-Cumulativeall-causemortalityMERIT-HFStudyGroup.Lancet1999;353:2001–7.Follow
显示全部收起
温馨提示:
1. 部分包含数学公式或PPT动画的文件,查看预览时可能会显示错乱或异常,文件下载后无此问题,请放心下载。
2. 本文档由用户上传,版权归属用户,天天文库负责整理代发布。如果您对本文档版权有争议请及时联系客服。
3. 下载前请仔细阅读文档内容,确认文档内容符合您的需求后进行下载,若出现内容与标题不符可向本站投诉处理。
4. 下载文档时可能由于网络波动等原因无法下载或下载错误,付费完成后未能成功下载的用户请联系客服处理。