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1、Plan:Howcanweunderstandneurodegenerativedisease,suchasautism,ADHDorepilepsy?Whoisinthebestpositiontodoit?Theories,mistakingsymptomsforcauses.Whatdowehopefor?Computationalexperiments.Experimentalevidence,geneticsSomeideasforneurorehabilitation&ICNT.Apriliscel
2、ebratedastheautismawarenessmonthsince1970.InterdisciplinaryCenterofInnovativeTechnologiesWhyamIinterestedinthis?ICITinconstruction,endof2012?Neurocognitivelab,5rooms,manyprojectsrequiringexperiments.WorkingonEUgrant.Understandingbrainplasticity,mindstates
3、.AbitofASDhistoryASD:AutismSpectrumDisorder,includesmanyformsofautism.Describedforthefirsttimein1943byLeoKanner:“extremealonenessfromthebeginningoflifeandanxiouslyobsessivedesireforthepreservationofsameness.”“…thesechildrenhavecomeintotheworldwithinnateinabi
4、litytoformtheusual,biologicallyprovidedaffectivecontactwithpeople…”.Commondeficit:lackofthetheoryofmind.Initialtheories:badparents,refrigeratormothers...abehavioralsyndrome…adevelopmentalsyndrome...multiplediseaseentities,multipleetiologies,includingmetaboli
5、candimmunesystemderegulation,genetics.2008:However,asinmanyareasofneuroscience,weare‘‘datarichandtheorypoor’’(Zimmerman,Autism–currenttheories).ASDAutismSpectrumofDisordersincludes:Autism,Aspergersyndrome,pervasivedevelopmentaldisordernototherwisespecified(
6、PDD-NOS),atypicalformsofchildhooddisintegrativedisorder,Rettsyndrome,InfantileAutisticBipolarDisorder(IABD),purineautism.4-5timesmoreboysthangirls.CDCestimates:averageabout1%,boysabout2%.AutisticSavants:fewpercentofpeoplewithASDlearnunusualmemoryormotorskill
7、s,butareimpairedinmanyotherways.AutismSymptoms...Epidemics?Notclearwhy:moreattention,betterdiagnostics?Verydiverse,notasingledisease,butmorelikedementia.Geneticcomponent,butsearchfor“autismgenes”nottoosuccessful,toomanyareinvolved.Geneticscannotexplainrecent
8、rapidincrease.ADHDAttentionDeficitHyperactivityDisorder,3-5%ofpopulation(alsoadults).Problemswithattention:usuallyimpulsive-hyperactive,inattentive(ADD)Lackofimpulsecontrol,easilydistracted,mis