聚桂醇泡沫硬化剂治疗下肢静脉曲张临床观察

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1、聚桂醇泡沫硬化剂治疗下肢静脉曲张的临床观察刘小平1，郭伟1，贾鑫1，杜昕1，熊江1，尹太1，张宏鹏1，刘蒙1，温朝阳2（1.解放军总医院血管外科，北京100853；2.解放军总医院超声科，北京100853）[摘要]目的：探讨国产聚桂醇作为新型泡沫硬化剂治疗下肢静脉曲张的临床效果。方法：选择我院2008年4-8月间30例下肢静脉曲张的患者，对其进行导管引导下患肢大隐静脉主干内注射1%聚桂醇泡沫硬化剂，观察大隐静脉主干的闭合情况。结果：30条患肢均在导管引导下成功注射泡沫硬化剂，平均每条患肢应用6.2ml泡沫硬化剂。27条（90%）大隐静脉主干治疗后即刻可见反流消失，

2、27条患肢（90%）于治疗后2周、3个月后复诊血管超声示大隐静脉主干闭塞。平均随访3个月时，27例患者下肢活动后酸胀、乏力感消失，下肢明显的曲张畸形静脉消失；4例患者（15%）仅有小腿局限的轻度曲张。无严重并发症发生，轻微浅静脉炎5例，2周内自行缓解。结论：国产聚桂醇泡沫硬化剂疗法治疗下肢静脉曲张的临床效果满意，是微创治疗下肢静脉曲张的新方法。[关键词]聚桂醇；泡沫；硬化疗法；静脉曲张；导管[中图分类号]R969.4[文献标识码]A[文章编号]1672-8157（2010）02-0073-03Effectobservationoffoamsclerotherapy

3、oflauromacrogolforvaricoseveinsoflowerextremityLIUXiao-ping1,GUOWei1,JIAXin1,DUXin1,XIONGJiang1,YINTai1,ZHANGHong-peng1,LIUMeng1,WENChao-yang2(1.DepartmentofVascularSurgery,PLAGeneralHospital,Beijing100853,China;2.DepartmentofUltrasound,PLAGeneralHospital,Beijing100853,China)[ABSTRACT

4、]Objective:Toexploretheclinicaleffectofdomesticlauromacrogolasanewfoamsclerosingagentinthetreatmentofvaricoseveinsoflowerextremity.Methods:Thedataof30p--atientswithvaricoseveinswhoweretreatedwith1%lauromacrogolfoamsclerosingagentinser--tedinthegreatsaphenousvein(GSV)throughacatheterwa

5、scollectedfromApriltoAugust2008inourhospital,andtheocclusionsofGSVin2weeksand3monthsafterthetreatmentwereobserved.Results:Thirtypatientsweresuccessfullytreatedbycatheter-directedfoamsclerothe--rapy.Theaveragevolumeoffoamsclerosingagentineachcasewas6.2mL.AxialrefluxinGSVdisappearedimme

6、diatelyin27of30patients(90%)afterthetreatment.Therewere27patients(90%)showingtheocclusionsofGSVexaminedbycolourduplexvascularultrasoundin2weeksand3monthsaftertheprocedure.Obviousabnormalvaricoseveinsaswellasthesorenessandfatigueoflowerextremitydisappearedin27patientsin3-monthfollowup.

7、Mildandlocalizedvaricoseveinsoflegwerefoundin4patients(15%).Noseverecomplicationwasreported.Fivepatientsdevelopedsuperficialphlebitis,whilethesymptomwasspontaneousremissionintwoweeks.Conclusion:Theeffectofdomesticlauromacrogolfoamsclerosingagentinthetreatmentofvaricoseveinswasconsider

8、able,