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1、早孕前后子宫动脉血流变化与妊娠结局的相关研究1山东省潍坊市人民医院产二科山东潍坊261041;2.山东省潍坊市人民医院习惯性流产科山东潍坊261041[摘要]目的:通过对育龄期正常及复发性流产(RecurrentSpontaneousAbortion,RSA)妇女备孕前1个月及孕后10周内子宫动脉血流(uterineartery,UtA)动力学系统相关指标的观察,了解月经周期的黄体期及孕10周内UtA动力学特点及其对妊娠结局的影响。方法:将既往无不良妊娠史的育龄期妇女250例及既往有3次及以上的自然流产史妇女168例进行月经周期的排卵后及孕10周内经阴道超
2、声监测双侧子宫动脉血流动力学参数,分别为:S/D^ft缩期峰值流速(S)/舒张末期流速(D)。阻力指数(Rl)=S-D/S;记录各组的Rl,S/D,对照统计各组子宫动脉Rl、S/D值及妊娠丢失率的差异。结果:1.孕前后或孕后子宫动脉血流异常者与正常者相比较,妊娠结局有显著性差异(P<0.05)2.孕前后或孕后子宫动脉血流值异常者未治疗与治疗后孕10周内恢复正常者Rl、S/D及妊娠丢失率均有统计学意义(P<0.05)3.RSA患者孕前异常血流纠正后,孕后子宫动脉血流异常率降低及其孕后异常血流治疗恢复率升高,与孕前未纠正者相比较,有统计学差异(P&
3、lt;0.05)o结论:1.孕早期子宫动脉血流参数与妊娠结局有相关性。2.异常血流早期纠正,能显著改善妊娠结局。3.RSA患者孕前子宫动脉血流参数影响妊娠结局。[关键词]:子宫动脉血流参数;早期妊娠;彩色多普勒超声;复发性流产;妊娠不良结局BeforepregnancyrelatedresearchafteruterinearterybloodflowchangesandpregnancyoutcomesWanglilGengShunling2FuJinhua3(1,3WeifangPeople'sHospital,WeifangShandong26104
4、1,China)Correspondingauthor:FuJinhua[Abstract]AIM:Toobservethe10weeksoftheuterinearterybloodflow(uterineartery,UtA)dynamicalsystemsrelatedindicatorsofreproductiveagethroughthenormalandrecurrentmiscarriageforwomen(RecurrentSpontaneousAbortion,RSA)preparedamonthbeforepregnancyandaft
5、erpregnancyunderstandthelutealphaseofthemenstrualcycleandpregnancy10weeksUtAdynamicsandimpactonpregnancyoutcome.METHODS:Afternoprevioushistoryofadversepregnancywomenofchildbearingageandprevioushistoryofthreetimesandover250casesofspontaneousabortion(RSA)168casesofwomeninthemenstrua
6、lcycleandovulationcarriedout10weeksofpregnancybytransvaginalultrasoundmonitoringofuterinearterybloodhemodynamicparameters,namely:Resistanceindex(Rl)=S-D/S;S/D=peaksystolicvelocity/diastolicvelocity.Rlrecordsineachgroup,S/D,statisticaldifferencesbetweenthegroupsincontrolofuterinear
7、teryRlvalue,S/Dvalueandpregnancylossrate.RESULTS:1,pre-pregnancy,abnormaluterinearterybloodflowcomparedwithnormalpregnancyoutcomesweresignificantdifferences(P<0.05)2,pregnancy,uterinearterybloodflowvalues??orpregnancyaftertreatmentandaftertreatmentisnotabnormalpregnancyreturned
8、tonormalafter10weeks,RlandS/Dandp