地佐辛超前镇痛在人工流产术的临床研究

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1、地佐辛超前镇痛在人工流产术的临床研究广东省肇庆市端州IX妇幼保健院526040【摘要】目的观察地佐辛超前镇痛联合丙泊酚在人工流产术中的镇痛效果和不良反应。方法早孕妇女120例，ASAI〜II级，停经6〜10周。无心血管疾患，无手术及麻醉药物禁忌。随机分成3组，每组40例。A组：地佐辛5mg与丙泊酪复合静脉麻醉；B组：芬太尼lμg·kg-l与丙泊酪复合静脉麻醉，C组：单纯丙泊酚静脉麻醉。三组丙泊酚诱导剂量均是2mg·kg-lc观察指标:包括生命体征，诱导时间，苏醒时间，离院时间，丙泊酚总用量，术中（体动）、术后（下腹痛）的镇痛效果和不良反应。结果A,B两组的诱导

2、时间，丙泊酚总用量明显少于C组，有统计学意义（P0.05）;苏醒、离院时间三组没有明显的差异；镇痛效果比较：三组患者术中镇痛效果A,B两组占优秀的显著高于C组，有统计学意义（P0.05），患者术后下腹疼痛程度的VAS评分，A,B两组显著轻于C组，有统计学意义（P0.05）;在呼吸抑制方面A,C两组显著轻于B组，有统计学意义（P0.05）。A组生命体征较平稳。结论地佐辛超前镇痛联合丙泊酚麻醉用于人流术优于芬太尼联合丙泊酚麻醉和单纯异丙酚麻醉，安全，有效，值得临床推广使用。【关键词】地佐辛；超前镇痛；丙泊酚；人工流产术[Abstract]Objective：Toobservetheanalgesi

3、ceffectofdezocinepreemptiveanalgesiacombinedwithpropofolinartificialabortionandadversereaction.Methods120casesofearlypregnancywomen,ASAI〜II，6〜10weeksmenolipsis.Nocardiovasculardisease，nooperationandanesthesiadrug.Wererandomlydividedinto3groups，40casesineachgroup.GroupA：dezocine5mgandpropofolintraven

4、ousanesthesia；groupB：1gkg-1,fentanylandpropofolintravenousanesthesia，groupC：simpleintravenousanesthesiawithpropofol.Threegroupsofpropofolinduceddosewas2mg•kg-1.Observationindexes：includingvitalsigns，inductiontime,recoverytime,thetimetoleavethehospital，thetotaldosageofpropofol，intraoperative,postoper

5、ative(motion)(abdominalpain)ofanalgesiceffectandadversereaction.TheresultsofA,Btwogroupsofinductiontime，totaldosageofpropofolwasobviouslylessthangroupC，withstatisticalsignificance(P0.05)；awake，leavehospitaltimethreegroupshadnoobviousdifferences；tocomparetheanalgesiceffect：theanalgesiceffectofpatient

6、sinthreegroupsofA,BtwogroupwassignificantlyhigherthanthatofCgroupaccountedforgood,therearestatisticssignificance(P0.05)inpatientswithpostoperativeabdominalpaindegree,VASscore,A,BtwogroupwassignificantlylighterthanthatofCgroup，therewasstatisticalsignificance(P0.05)；theinhibitionofAonrespiration，Ctwog

7、roupwassignificantlylighterthanthatofBgroup,therewerestatisticallysignifican(tP0.05).VitalsignswerestableingroupA.Conclusiondezocinepreemptiveanalgesiacombinedwithpropofolanesthesiaforinducedabortioni