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时间:2018-10-13
《多发性硬化患者伴发抑郁的发生率及相关因素研究》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、多发性硬化患者伴发抑郁的发生率及相关因素研究王焱烽李明超陈敏蒋苏莉江苏省淮安市第一人民医院神经内二科江苏淮安223300【摘要】目的研宄多发性硬化(MS)患者抑郁的发生率及相关因素.方法应用汉密尔顿抑郁量表(HAMD)对45例MS患者和40名健康体检者进行抑郁评定,以及对MS患者进行日常生活能力量表(A叫评分兹堡睡眠质量指数量表(PSQI)评分.结果45例MS患者18例(40.0%)伴发抑郁,其中轻度抑郁12例(26•7%),中度抑郁5例(11.1%),重度抑郁1例(2.2%);40例对照组中5例(12.5%)伴发抑郁,其中轻度4例(10%),中度抑郁1例(2.5%).两组相比较差异有
2、统计学意义.(X2=21.458,11.045,4.89,P<0.01).MS患者抑郁组与非抑郁组PSQI总分及各因子比较显示PSQI总分、主观睡眠质量(F1)、入睡时间(F2)、睡眠干扰(F5)差异有统计学意义.抑郁与MS患者ADL评分,睡眠质量,左侧大脑半球病灶,性别相关,(P<0.01).结论MS患者有较高的抑郁发生率,抑郁的程度与ADL评分,睡眠质量,幕上病灶数,性别相关.【关键词】多发性硬化;抑郁;日常生活能力评分【Abstract】ObjectiveTostudytheincidenceandrelatedfactorsofMultiplesclerosis(MS)pati
3、entswithdepression"Methods45Multiplesclerosis(MS)p(atientsand40healthysubjectswereassessedwithHamiltonDepressionScale(HAMD),aswellasMSpatientswereassessedwithactivitiesofdailylivingADL)scoreandPittsburghSleepQualitylndexScale(PSQI)score4、licatedbydepresGsion.12cases(26.7%)milddepression,5cases(11.1%)moderatedepression,onecase(2.2%)severedepression.Of40casesinthecontrolgroup,5cases(12.5%)wereComplicatedbydepression.4cases(10%)milddepression,onecase(2.5%)moderatedepression.Thereweresignificantstatisticallydifferentbetweentwogroups5、(X2=21.458,11.045,4.89,P<0.01).DifferentenceofPSQIscores,subjectivesleepquality(F1),sleeptime(F2),sleepdisturbances(F5)betweendepressiongroupandnon—depressiongroupwerestatisticallysignificant.MSpatientswithdepressionwererelatedwithADLscore,qualityofsleep,theleftcerGebralhemispherelesionsandgende6、rofpatients(P<0.01).ConclusionsMSpatientshaveahigherincidenceofdepression;MSpatientswithdepressionwerereGlated【wKietyhAwoDrLdss】cores,qualityofsleep,numberoflesionsonthescreen,andgender.Multiplesclerosis:depression:activitiesofdailyliving(ADL)score【中图分类号】R744.5【文献标识码】B【文章编号】1008—6315(2015)12—0097、4—02多发性硬化是一种以中枢神经系统白质脱髓鞘改变为特点的自身免疫性疾病,由于病程长,反复发作,致残率高,患者会产生精神负担和抑郁情绪,但临床相关研宄较少,为此,我们对我院45例MS患者伴发抑郁及相关进行分析.1资料与方法1.1一般资料2004年4月至2008年5月神经内科住院病人确诊为MS(复发一缓解型)的患者45例(男17例,女28例),年龄22-52岁,平均38.1±4.3岁.所存患者均符合McDonald(2001h多发
4、licatedbydepresGsion.12cases(26.7%)milddepression,5cases(11.1%)moderatedepression,onecase(2.2%)severedepression.Of40casesinthecontrolgroup,5cases(12.5%)wereComplicatedbydepression.4cases(10%)milddepression,onecase(2.5%)moderatedepression.Thereweresignificantstatisticallydifferentbetweentwogroups
5、(X2=21.458,11.045,4.89,P<0.01).DifferentenceofPSQIscores,subjectivesleepquality(F1),sleeptime(F2),sleepdisturbances(F5)betweendepressiongroupandnon—depressiongroupwerestatisticallysignificant.MSpatientswithdepressionwererelatedwithADLscore,qualityofsleep,theleftcerGebralhemispherelesionsandgende
6、rofpatients(P<0.01).ConclusionsMSpatientshaveahigherincidenceofdepression;MSpatientswithdepressionwerereGlated【wKietyhAwoDrLdss】cores,qualityofsleep,numberoflesionsonthescreen,andgender.Multiplesclerosis:depression:activitiesofdailyliving(ADL)score【中图分类号】R744.5【文献标识码】B【文章编号】1008—6315(2015)12—009
7、4—02多发性硬化是一种以中枢神经系统白质脱髓鞘改变为特点的自身免疫性疾病,由于病程长,反复发作,致残率高,患者会产生精神负担和抑郁情绪,但临床相关研宄较少,为此,我们对我院45例MS患者伴发抑郁及相关进行分析.1资料与方法1.1一般资料2004年4月至2008年5月神经内科住院病人确诊为MS(复发一缓解型)的患者45例(男17例,女28例),年龄22-52岁,平均38.1±4.3岁.所存患者均符合McDonald(2001h多发
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