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1、NursingofDrugApplicationLecturer:CaimeiZhengDep.ofPharmacyMay.30th,20091three“W”WhoWhereWhat2TheaimofthiscourseToidentifythepackageinsertofdrugsTocarryoutdoctor’sadviceToexplainhowtousedrugsproperlyToreadpharmacologicalliteratureinEnglish(terminology)3Learningmethod(1)recite(words/terms
2、、typicaldrugs)(2)speak(pronunciation)4FinalExamAccountfor30%ofthetotalscoreForm:singlechoiceblanking5metabolism[mi’tæbəlizəm]n.代谢作用inhibit[in’hibit]vt.阻止;抑制therapeutic[,θerə’pju:tik]adj.治疗(学)的agonist[‘æɡənist]n.激动剂antagonist[æn‘tæɡənist]n.拮抗剂teratogenesis[,terətəu’dʒenisis]n.致畸carcinoge
3、nesis[,kɑ:sinə’dʒenisis]n.致癌mutagenesis[,mjutə’dʒenisis]n.致突变pharmacodynamics[fɑ:mə,kəudai’næmiks]n.药效学6Chapter1GeneralPrinciples section1IntroductionDrug：isasubstanceusedinthediagnosis,treatment,preventionofadiseaseorfamilyplanning,whichcanaffectorganictissuesandcellularmetabolism.7Sec
4、tion2Pharmacodynamics药效学1.TheActionofDrug1.1fundamentalactionofdrugStimulatingactionInhibitingaction81.2twofold（两重性）charactersofdrugactionpreventiveandtherapeuticeffect防治作用adversereaction不良反应9adversereaction：sidereaction副反应-----therapeuticdosetoxicreaction毒性反应------aheavydose,fortoolong
5、allergicreaction过敏反应------immuneresponseteratogenesis致畸“threegenicityreactions”三致作用carcinogenesis致癌mutagenesis致突变102.mechanismofdrugactionReceptorTheory受体理论----themostimportantmechanismofdrugactionAffinityIntrinsicactivityconditions11Agonist----isacompoundthatbindstoareceptorandproduces
6、thebiologicalresponse.Antagonist----bindstoareceptorbutdoesnotproduceabiologicaleffect.Partialagonist12diffusion[di’fju:ʒən]n.扩散absorption[əb’sɔ:pʃən]n.吸收distribution[,distri’bju:ʃən]n.分布excretion[eks’kri:ʃən]n.排泄eliminate[i’limineit]vt.消除,排除administration[əd,minis‘treiʃən]n.给药sublingua
7、l[sʌb’liŋɡwəl]adj.舌下的rectal[‘rekt(ə)l]adj.直肠的13intravenous[,ɪntrə’vi:nəs]adj.静脉内的subcutaneous[,sʌbkju:’teiniəs]adj.皮下的intramuscular[,intrə‘mʌskjulə]adj.肌肉的transdermal[træns’də:məl]adj.经皮吸收的inhalation[,inhə’leiʃən]n.吸入gastrointestinal[,ɡæstrəuin’testənl]adj.肠胃的pharmacokinetics[,
