如何用ppt讲解英文文献课件

《如何用ppt讲解英文文献课件》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、NameEmail3/7/2012JournalClubH2BubiquitinationmediatedbyRad6/Bre1H2AubiquitinationmediatedbyPRC1KnockoutBmi-1resultsinsignificantlossofH2AubiquitylationandupregulationofHoxc13expression,whereasEZH2-mediatedH3-K27methylationisnotaffected.Ourresultssugges

2、tthatEZH2-mediatedH3-K27methylationfunctionsupstreamofPRC1andestablishesacriticalroleforBmi-1andRing1AinH2AubiquitylationandHoxgenesilencing.Thestuctureof2A-HUBnuclearreceptorco-repressor1NR:nuclearreceptorsGPS2:Gproteinpathwaysuppressor2TBL1:transduci

3、nbetalike1N-CoR:nuclearreceptorco-repressor1InteractionbetweenNCoR/HDAC1/3componentsand2A-HUB2A-HUBmediatedtranscriptionrepression2A-HUBmonoubiquitinateshistoneH2Ainvitro2A-HUBmonoubiquitinateshistoneH2Ainvitro2A-HUBmonoubiquitinateshistoneH2AinvivoCo

4、nclusion12A-HUBfunctionsasatranscriptionalrepressor,andcanspecificallymonoubiquitinateH2Ainvitroandinvivo.2A-HUBandN-CoRregulateasubsetofchemokinegeneexpression2A-HUBandN-CoRregulateasubsetofchemokinegeneexpression2A-HUBandN-CoRregulateasubsetofchem

5、okinegeneexpressionTherecruitmentof2A-HUBanduH2AonthetargetgenepromotersConclusion22A-HUBandN-CoRregulateasubsetofchemokinegeneexpression.CoimmunoprecipitationofSpt16andH2A/H2BChIPanalysisoftheendogenousRANTESpromoterChIPanalysisoftheendogenousRANTESp

6、romoterModelConclusion3H2Aubiquitinationmediatedby2A-HUBnegativelyregulatestranscriptionalelongationbypreventingFACTrecruitment.Summary2A-HUBfunctionsasatranscriptionalrepressor,andcanspecificallymonoubiquitinatesH2Ainvitroandinvivo.2A-HUBandN-CoRregul

7、ateasubsetofchemokinegeneexpression.H2Aubiquitinationmediatedby2A-HUBnegativelyregulatestranscriptionalelongationbypreventingFACTrecruitment.Thanksforyourattention!