杜氏进行性肌营养不良症课件

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1、DuchenneMuscularDystrophySherriGarciaMuscularDystrophy:WalkaMileinTheirShoesCDC’s2005ScienceAmbassadorProgramOverviewSympathyvs.empathyBasicinformationaboutDuchennemusculardystrophyInheritancePrevalenceSymptomsTreatmentsUnderstanding(4)SympathyAfeelingoranexpressionofpityorsorrowforthe

2、distressofanother;compassionorcommiserationEmpathyIdentificationwithandunderstandingofanother'ssituation,feelings,andmotivesUnderstanding(4)WhatIsDuchenneMuscularDystrophy?(1)GeneticProgressivemuscleweaknessDefectsinmuscleproteinsDeathofmuscletissueWhereisThisGene?DuchenneMuscularDystro

3、phyInheritance(1)MothercarriestherecessivegeneandpassesittoherchildTraitisusuallyexpressedinmalesonlyPunnettSquareLinkPrevalenceofDMD(1)Affectsonein3500to5000newbornmales1/3ofthesewithpreviousfamilyhistory2/3sporadicSymptomsofDMD(1)DelayeddevelopmentalmilestonesLossofmotorskillsCharacte

4、risticgaitCalfhypertrophyClumsiness/frequentfallsMoreSymptomsofDMD(1)MuscleweaknessDifficultyclimbingstairsorhillsDifficultyrising(Gower’ssign)Difficultywalking/runningLinktoGower'sSignTreatmentsforDMD(1)Toimprovebreathing:O2therapyVentilatorScoliosissurgeryTracheotomyTreatments(cont.)(

5、1)Toimprovemobility:PhysicaltherapySurgeryontightjointsPrednisoneNon-steroidalmedicationsWheelchairTheBeginningofGeneTherapyforDMD(2)AdvancesinGeneTherapy(3)Researcheshavedeveloped"minigenes,"whichcarryinstructionsforaslightlysmallerversionofdystrophin,thatcanfitinsideavirusResearchersh

6、avealsocreatedtheso-calledguttedvirus,avirusthathashaditsowngenesremovedsothatitiscarryingonlythedystrophingeneProblemswithGeneTherapy(3)MuscletissueislargeandrelativelyimpenetrableVirusesmightprovoketheimmunesystemandcausethedestructionofmusclefiberswiththenewgenesSummaryEmpathyvs.symp

7、athyDefinitionofmusculardystrophyInheritancePrevalenceSymptomsTreatmentsMakingRealSenseoftheSensesbyMattieStepanekOureyesareforlookingatthings.ButtheyarealsoforcryingWhenweareveryhappyorverysad.Ourearsareforlistening,Butsoareourhearts.Ournosesareforsmellingfood,Butalsothewindan