血脑屏障相关知识课件

《血脑屏障相关知识课件》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、blood-brainbarrier(BBB)HuafuQ:279486524KeyfunctionsoftheBBBDiscoveryoftheblood-brainbarrierAnatomyoftheblood-brainbarrierCircumventricularorgansFactorsthatcanlowertheblood-brainbarrierBlood-brainborderandGlucoseBlood-brainbarrierpermeabilityinthemousebrainOutlineKeyfunctionsoftheBBBAmechanismthat

2、controlsthepassageofsubstancesfromthebloodintothecerobrospinalfluidandthusintothebrainandspinalcord.Theblood-brainbarrier(BBB)letsessentialmetabolites,suchasoxygenandglucose,passfromthebloodtothebrainandcentralnervoussystem(CNS)butblocksmostmoleculesthataremoremassivethanabout500daltons.Thisisalo

3、wmassinbiomoleculartermsandmeansthateverythingfromhormonesandneurotransmitterstovirusesandbacteriaarerefusedaccesstothebrainbytheBBB.Italsomeansthatmanydrugs,whichwouldotherwisebecapableoftreatingdisordersoftheCNS,aredeniedaccesstotheveryregionswheretheywouldbeaffective.KeyfunctionsoftheBBBare:Pr

4、otectingthebrainfrom"foreignsubstances"(suchasvirusesandbacteria)inthebloodthatcouldinjurethebrainShieldingthebrainfromhormonesandneurotransmittersintherestofthebodyMaintainingaconstantenvironment(homeostasis)forthebrainDiscoveryoftheblood-brainbarrierThespecialpropertiesoftheblood-brainbarrierwe

5、refirstobservedinthelate19thcenturybytheGermanbacteriologistPaulEhrlich.Hefoundthatwhenheinjectedcoloreddyesintothebloodstreamtheyleakedoutofcapillariesinmostregionsofthebodytostainthesurroundingtissues;thebrain,however,remainedunstained.Ehrlichwronglysurmisedthatthebrainhadalowaffinityforthedyes

6、.Itwashisstudent,EdwinGoldman,whodidtheotherhalfoftheexperimentandrealizedthetruthofwhatwasgoingon.Goldmaninjectedadyeintothecerebrospinalfluidthatsurroundsthebrainandobservedthatitstainedthebrain,butnothingelse.Goldmanncorrectlyconcludedthatthedyewasunabletocrossthespecializedwallsofbraincapilla

7、ries.Anatomyoftheblood-brainbarrierDiagramoftheblood-brainbarriertransversetoacapillary(A)Diagramofabraincapillaryincrosssectionandreconstructedviews,showingendothelialtightjunctionsandtheinvestmentofthecapillarybyastr