先天性甲状腺功能减退 ppt课件

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1、CONGENITALHYPOTHYROIDISM5thYearIntern-AmilaKannangara1Clinicalscenario..Apregnantmotherwithherhusbandcomestoseeyou.Sheisinherthirdtrimester.Bothofthemarelawyers.TheyhaverecentlyheardaboutcongenitalhypothyroidisminTelevisionandwantstodiscusswithyouhowtoknowiftheirun

2、bornchildisaffected.2Howwillyouadvicethem?Content…1.WhatiscongenitalHypothyroidism?2.CausesbehindCH?3.SignsandsymptomsofCH?4.HowtodiagnoseCH?5.IsCHinherited?6.HowtotestforCH?7.TreatmentofCH?3WhatisCongenitalHypothyroidism?Isastateofinadequatethyroidhormoneproduction

3、innewborninfants.4Babieswhodonothaveenoughthyroidhormoneareoftenslowtogrow,aresluggish,andhavelearningdelaysandotherspecifichealthproblems.Whatarethecausesforthiscondition?1.Missingormisplacedthyroidgland5MostbabieswithCHaremissingtheirthyroidglandorhaveathyroidthat

4、didnotdevelopproperly. Insomecases,thethyroidglandmaybesmallerthanusualormaynotbelocatedinthecorrectplace.InsomechildrenwithCH,thethyroidglandmayinsteadbeunderthetongueoronthesideoftheneck.2.HereditarycausesChildrenwiththeinheritedtypeofCHdonotmakeenoughthyroidhormo

5、neeventhoughtheirthyroidglandappearsnormalinsizeandshape.3.Maternaliodinedeficiency4.Maternalthyroidconditionandmedications5.Multiplebirthswhatproblemsoccur?.Poorfeedingandpoorsuck.Lowactivitylevel.Fewerbowelmovementsorconstipation.Swellingaroundtheeyes.Cool,pale,dr

6、yskin.thefontanelthatcloseslate61.Jaundice2.Hypotonia3.Umbilicalhernia4.LargeswollentongueIfleftuntreatedCoarse,swollenfacialfeaturesBreathingproblemsHoarse-soundingcryDelayedmilestones(sitting,crawling,walking,talking)Wide,shorthandsPoorweightgainandgrowthGoiter(en

7、largedthyroidglandcausingalumpintheneck)AnemiaSlowheartrateFluidbuild-upundertheskin(calledmyxedema)Hearingloss7HowtodiagnoseCH?Familyhistoryshouldbecarefullyreviewedforinformationaboutsimilarlyaffectedinfantsorfamilymemberswithunexplainedmentalretardation.8Maternal

8、historyofathyroiddisorderandmodeoftreatment(whetherbeforeorduringpregnancy)WhatisthechanceofCHbeinginherited?About80to85%ofthetime,CHiscau