呼吸机相关性肺损伤郑州

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1、欧阳彬SICU中山大学附属第一医院,广州呼吸机相关性肺损伤（Ventilatorinducedlunginjury,VILI)(Ventilatorassociatedlunginjury,VALI)中山大学附属第一医院机械通气挽救了无数患者的生命脊髓灰质炎1952年无呼吸机时死亡率87%，1953年有呼吸机后死亡率15%但机械通气同时导致了呼吸机相关性肺损伤（VALI）呼吸机诱导膈肌萎缩(VIDD)呼吸机相关性肺炎(VAP)呼吸机相关性不适（VAUE）InflammationHemorrhageEdemaFibrosi

2、sPulmonarydysfunctionSystemiceffects机械通气导致了怎样的肺损伤？1.B.Ouyang（欧阳彬),Jafari,O.Syrkina,C.A.HalesandD.A.Quinn.N-acetyl-L-cysteineinhibitedTGF-productionandreducedlungcollagenformationinventilator-inducedlunginjury.FASEBJournal.2004Mar:18(4):218.11(A323).2.BinOuyang（欧

3、阳彬),ChoiW,HalesC,QuinnD.TGFup-regulationinvitroandinvivomodelsofVentilatorInducedLungInjury.ATS2003,A622.3.BinOuyang（欧阳彬）,DeborahA.Quinn,andCharlesA.Hales.StretchInducedGeneExpressioninaninvitromodelofVentilatorInducedLungInjury(VILI).FASEBJournal.2002Mar:16(4):

4、367.10(A410).4.OuyangB（欧阳彬）,ChoukrounG,MatyalR,MascarenhasM,JafariB,BonyentreJV,ForceTandQuinnDA.Stretch-inducedIL-8dependsonc-JunNH2-terminalandnuclearfactor-kappaBinducingkinases.AmJPhysiolLungCellMolPhysiol.2003Aug;285(2):L464-75.5JafariB,OuyangB（欧阳彬）,LiLF,Hal

5、esCAandQuinnDA.Intracellularglutathioneinstretch-inducedcytokinereleasefromalveolartype-2likecells.Respirology.2004Mar;9(1):43-53.6.B.Jafari,B.Ouyang（欧阳彬),C.A.HalesandD.A.Quinn.Antioxidantsinhibitstretch-inducedIL-8productionthroughintracellularglutathione.ATS,20

6、02.B82.7.Li-FuLi,BinOuyang（欧阳彬）,DeborahA.Quinn.Stretch-InducedIL-8isDependentonc-JunN-TerminalKinaseandNuclearFactor-B-InducingKinasePathwaysATS2003,C112.8.Li-FuLi,BinOuyang（欧阳彬）,BehrouzJafari,CharlesA.Hales,DeborahA.Quinn.StretchInducesIL-8PromoterActivityandIL

7、-8mRNAExpressioninanInVitroModelofVentilatorInducedLungInjury(VILI).FASEBJournal.2002Mar:16(4):367.49.QuinnDA,JafariB,LiLF,MascarenhasM,OuyangB（欧阳彬）,SyrkinaO,andHalesCA.PulmonaryEpithelialCells,EndothelialCellsandFibroblastsContributetoLungStretch-InducedCytokine

8、ProductionFoundinVentilator-InducedLungInjury(VILI).FASEBJournal.2003,85.1(A88).10.MascarenhasMM,DayRM,OchoaCD,ChoiWI,YuL,OuyangB（欧阳彬）,GargHG,HalesCAandQuinnDA